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PMID: 16891673 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

IL-17A-producing neutrophil-regulatory Tn lymphocytes.

Immunologic research ·Vol. 34 ·No. 3 ·2006-00-00 ·Pages 229-42

Ley K, Smith E, Stark MA

Abstract

The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells. IL-17A-producing lymphocytes are most abundant in the mesenteric lymph node, where they account for 0.15% of all lymphocytes. About 60% of the Tn cells are gammadelta T cells, about 25% NKTlike cells, and less than 15% are CD4 T cells. These latter cells are also known as T-17 or ThIL-17 cells, a subset of Tn cells that also plays an important role in autoimmune diseases. IL-17A produced by Tn cells regulates the production of G-CSF, which in turn promotes the proliferation of promyelocytes and maturation of neutrophils. This homeostatic mechanism plays an important role in normal physiology and in host defense against bacterial infections. This review is aimed at highlighting the important role of IL-17A-producing T cells at the interface between the adaptive and innate immune system.

MeSH Terms
Animals Apoptosis/immunology,physiology Granulocyte Colony-Stimulating Factor/immunology Humans Interleukin-17/biosynthesis,immunology Interleukin-23 Interleukin-23 Subunit p19 Interleukins/immunology Mice Models, Molecular Neutrophils/immunology Phagocytes/immunology Receptors, Interleukin/biosynthesis,immunology T-Lymphocytes, Regulatory/immunology
Chemicals
IL17A protein, human IL23A protein, human Il23a protein, mouse Interleukin-17 Interleukin-23 Interleukin-23 Subunit p19 Interleukins Receptors, Interleukin Granulocyte Colony-Stimulating Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ley Klaus
Robert M. Berne Cardiovascular Research Center, Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22903, USA. klausley@virginia.edu
Smith Emily
Stark Matthew A
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:34:3:229
Email
klausley@virginia.edu
Published
2006-00-00
Pages
229-42
Language
English
Region
United States
NLM ID
8611087
Subset
IM
Grants
NHLBI NIH HHS · HL54136 · United States
External Links
PubMed source DOI: 10.1385/IR:34:3:229 View journal details
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