IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.

The Journal of biological chemistry ·Vol. 276 ·No. 2 ·2001-01-12 ·Pages 1660-4

Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, Gurney AL

Abstract

We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.

MeSH Terms

Amino Acid Sequence Animals Cell Line Conserved Sequence Female Gene Library Humans Interleukin-17/chemistry,genetics,metabolism Interleukin-8/biosynthesis Kidney/immunology Leukemia, Experimental/immunology,virology Male Mice Molecular Sequence Data NF-kappa B/metabolism Organ Specificity Protein Isoforms/chemistry,genetics,metabolism RNA, Messenger/genetics Receptors, Interleukin/genetics,metabolism Receptors, Interleukin-17 Recombinant Proteins/genetics,metabolism,pharmacology Sequence Alignment Sequence Homology, Amino Acid Transcription, Genetic Transfection Virus Integration

Chemicals

IL17RA protein, human Il17ra protein, mouse Interleukin-17 Interleukin-8 NF-kappa B Protein Isoforms RNA, Messenger Receptors, Interleukin Receptors, Interleukin-17 Recombinant Proteins

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Lee J

Department of Molecular Biology, Genentech Inc., San Francisco, California 94080, USA.

Ho W H

Maruoka M

Corpuz R T

Baldwin D T

Foster J S

Goddard A D

Yansura D G

Vandlen R L

Wood W I

Gurney A L

Article Info

Journal

The Journal of biological chemistry

Abbr.

J Biol Chem

ISSN

0021-9258

DOI

10.1074/jbc.M008289200

Published

2001-01-12

Pages

1660-4

Language

English

Region

United States

NLM ID

2985121R

Subset

Databases

GENBANK

AF305200

External Links

PubMed source DOI: 10.1074/jbc.M008289200 View journal details

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IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.

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