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PMID: 16858390 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Glial inhibition of CNS axon regeneration.

Nature reviews. Neuroscience ·Vol. 7 ·No. 8 ·2006-08-00 ·Pages 617-27

Yiu G, He Z

Abstract

Damage to the adult CNS often leads to persistent deficits due to the inability of mature axons to regenerate after injury. Mounting evidence suggests that the glial environment of the adult CNS, which includes inhibitory molecules in CNS myelin as well as proteoglycans associated with astroglial scarring, might present a major hurdle for successful axon regeneration. Here, we evaluate the molecular basis of these inhibitory influences and their contributions to the limitation of long-distance axon repair and other types of structural plasticity. Greater insight into glial inhibition is crucial for developing therapies to promote functional recovery after neural injury.

MeSH Terms
Animals Axons/physiology Central Nervous System/physiology Humans Nerve Regeneration/physiology Neural Inhibition/physiology Neuroglia/physiology Spinal Cord Injuries/metabolism,physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yiu Glenn
Division of Neuroscience, Children's Hospital, Boston, Massachusetts 02115, USA.
He Zhigang
References (126)
126 references, click to expand
  1. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein.
    J Neurosci. 2005 Jan 26;25(4):808-22 PMID: 15673660
  2. The Nogo signaling pathway for regeneration block.
    Annu Rev Neurosci. 2004;27:341-68 PMID: 15217336
  3. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.
    J Neurosci. 2004 Jul 7;24(27):6209-17 PMID: 15240813
  4. Studies on the development and behavior of the dystrophic growth cone, the hallmark of regeneration failure, in an in vitro model of the glial scar and after spinal cord injury.
    J Neurosci. 2004 Jul 21;24(29):6531-9 PMID: 15269264
  5. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G.
    J Neurosci. 2004 Jul 28;24(30):6826-32 PMID: 15282288
  6. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury.
    Neuron. 2004 Oct 28;44(3):439-51 PMID: 15504325
  7. Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats.
    Science. 1981 Nov 20;214(4523):931-3 PMID: 6171034
  8. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors.
    J Neurosci. 1985 Sep;5(9):2415-23 PMID: 4032004
  9. Neuronal cell-cell adhesion depends on interactions of N-CAM with heparin-like molecules.
    Nature. 1986 Apr 3-9;320(6061):445-7 PMID: 3083264
  10. The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily.
    J Cell Biol. 1987 Apr;104(4):957-65 PMID: 2435742
  11. Neural protein 1B236/myelin-associated glycoprotein (MAG) defines a subgroup of the immunoglobulin superfamily.
    Immunol Rev. 1987 Dec;100:129-51 PMID: 2450062
  12. Ocular dominance plasticity in adult cat visual cortex after transplantation of cultured astrocytes.
    Nature. 1989 Nov 23;342(6248):427-30 PMID: 2586611
  13. The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.
    J Cell Biol. 1990 Feb;110(2):471-9 PMID: 1688857
  14. Glial membranes at the node of Ranvier prevent neurite outgrowth.
    Science. 2005 Dec 16;310(5755):1813-7 PMID: 16293723
  15. Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase.
    J Neurosci. 2006 Jan 18;26(3):1006-15 PMID: 16421320
  16. A class of membrane proteins shaping the tubular endoplasmic reticulum.
    Cell. 2006 Feb 10;124(3):573-86 PMID: 16469703
  17. Dendritic plasticity in the adult rat following middle cerebral artery occlusion and Nogo-a neutralization.
    Cereb Cortex. 2006 Apr;16(4):529-36 PMID: 16033928
  18. Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites.
    J Cell Biol. 2006 Mar 13;172(6):937-48 PMID: 16520383
  19. NG2 glial cells provide a favorable substrate for growing axons.
    J Neurosci. 2006 Apr 5;26(14):3829-39 PMID: 16597737
  20. Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury.
    J Neurosci. 2006 Apr 19;26(16):4406-14 PMID: 16624960
  21. Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment.
    J Neurosci. 2000 Nov 1;20(21):8061-8 PMID: 11050127
  22. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.
    Neuron. 2000 Oct;28(1):41-51 PMID: 11086982
  23. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.
    Nature. 2001 Jan 18;409(6818):341-6 PMID: 11201742
  24. Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.
    Genes Dev. 2001 Apr 1;15(7):877-88 PMID: 11297511
  25. Two-tiered inhibition of axon regeneration at the dorsal root entry zone.
    J Neurosci. 2001 Apr 15;21(8):2651-60 PMID: 11306618
  26. Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin.
    Glia. 2000 Jan 15;29(2):154-65 PMID: 10625334
  27. Inhibitor of neurite outgrowth in humans.
    Nature. 2000 Jan 27;403(6768):383-4 PMID: 10667780
  28. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.
    Nature. 2000 Jan 27;403(6768):434-9 PMID: 10667796
  29. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein.
    Nature. 2000 Jan 27;403(6768):439-44 PMID: 10667797
  30. Nervous system proteoglycans as modulators of neurite outgrowth.
    Prog Neurobiol. 2000 Jun;61(2):113-32 PMID: 10704995
  31. Lens injury stimulates axon regeneration in the mature rat optic nerve.
    J Neurosci. 2000 Jun 15;20(12):4615-26 PMID: 10844031
  32. Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.
    Nat Neurosci. 2001 May;4(5):465-6 PMID: 11319553
  33. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition.
    J Biol Chem. 2001 Jun 8;276(23):20280-5 PMID: 11279053
  34. Soluble myelin-associated glycoprotein released from damaged white matter inhibits axonal regeneration.
    Mol Cell Neurosci. 2001 Sep;18(3):259-69 PMID: 11591127
  35. Chondroitinase ABC promotes functional recovery after spinal cord injury.
    Nature. 2002 Apr 11;416(6881):636-40 PMID: 11948352
  36. Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions.
    J Neurosci. 2002 May 1;22(9):3553-67 PMID: 11978832
  37. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.
    J Cell Biol. 2002 May 13;157(4):565-70 PMID: 12011108
  38. Nogo-66 receptor antagonist peptide promotes axonal regeneration.
    Nature. 2002 May 30;417(6888):547-51 PMID: 12037567
  39. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.
    Nature. 2002 Jun 27;417(6892):941-4 PMID: 12068310
  40. Rho signaling pathway targeted to promote spinal cord repair.
    J Neurosci. 2002 Aug 1;22(15):6570-7 PMID: 12151536
  41. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth.
    Neuron. 2002 Jul 18;35(2):283-90 PMID: 12160746
  42. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.
    Science. 2002 Aug 16;297(5584):1190-3 PMID: 12089450
  43. Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substrates.
    J Biol Chem. 2002 Sep 6;277(36):32820-9 PMID: 12091381
  44. Activity-dependent synaptogenesis in the adult Mammalian cortex.
    Neuron. 2002 Sep 12;35(6):1015-7 PMID: 12354392
  45. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
    Nature. 2002 Nov 7;420(6911):74-8 PMID: 12422217
  46. Reactivation of ocular dominance plasticity in the adult visual cortex.
    Science. 2002 Nov 8;298(5596):1248-51 PMID: 12424383
  47. Chondroitin sulphate proteoglycans in the CNS injury response.
    Prog Brain Res. 2002;137:313-32 PMID: 12440375
  48. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.
    Nat Neurosci. 2002 Dec;5(12):1302-8 PMID: 12426574
  49. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1.
    J Neurosci. 2002 Dec 1;22(23):10368-76 PMID: 12451136
  50. Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse.
    J Neurosci. 2003 Jan 1;23(1):175-86 PMID: 12514214
  51. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue.
    J Neurosci Res. 2003 Feb 1;71(3):427-44 PMID: 12526031
  52. Changes in spinal cord regenerative ability through phylogenesis and development: lessons to be learnt.
    Dev Dyn. 2003 Feb;226(2):245-56 PMID: 12557203
  53. Rho kinase inhibition enhances axonal regeneration in the injured CNS.
    J Neurosci. 2003 Feb 15;23(4):1416-23 PMID: 12598630
  54. False resurrections: distinguishing regenerated from spared axons in the injured central nervous system.
    J Comp Neurol. 2003 Apr 21;459(1):1-8 PMID: 12629662
  55. The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar.
    Mol Cell Neurosci. 2003 Mar;22(3):319-30 PMID: 12691734
  56. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor.
    J Neurochem. 2003 May;85(3):717-28 PMID: 12694398
  57. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.
    Nat Neurosci. 2003 May;6(5):461-7 PMID: 12692556
  58. Axon regeneration in young adult mice lacking Nogo-A/B.
    Neuron. 2003 Apr 24;38(2):187-99 PMID: 12718854
  59. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury.
    Neuron. 2003 Apr 24;38(2):201-11 PMID: 12718855
  60. Lack of enhanced spinal regeneration in Nogo-deficient mice.
    Neuron. 2003 Apr 24;38(2):213-24 PMID: 12718856
  61. Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury.
    J Neurosci. 2003 May 15;23(10):4219-27 PMID: 12764110
  62. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.
    EMBO J. 2003 Jul 1;22(13):3291-302 PMID: 12839991
  63. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors.
    Neuron. 2005 Feb 3;45(3):345-51 PMID: 15694321
  64. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration.
    Neuron. 2005 Feb 3;45(3):353-9 PMID: 15694322
  65. Chondroitin sulfate proteoglycans in neural development and regeneration.
    Curr Opin Neurobiol. 2005 Feb;15(1):116-20 PMID: 15721753
  66. Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro.
    J Biol Chem. 2005 Apr 22;280(16):16305-10 PMID: 15701648
  67. Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury.
    Mol Cell Neurosci. 2005 May;29(1):26-39 PMID: 15866044
  68. In vivo imaging of axonal degeneration and regeneration in the injured spinal cord.
    Nat Med. 2005 May;11(5):572-7 PMID: 15821747
  69. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth.
    Neuron. 2005 Jun 16;46(6):849-55 PMID: 15953414
  70. Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex.
    Nature. 2005 Jul 14;436(7048):261-5 PMID: 16015331
  71. Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth.
    Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10694-9 PMID: 16020529
  72. Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord.
    J Neurosci. 2005 Aug 31;25(35):8066-76 PMID: 16135764
  73. Delayed treatment with monoclonal antibody IN-1 1 week after stroke results in recovery of function and corticorubral plasticity in adult rats.
    J Cereb Blood Flow Metab. 2005 Oct;25(10):1366-75 PMID: 15889044
  74. Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.
    Science. 2005 Sep 30;309(5744):2222-6 PMID: 16195464
  75. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.
    Science. 2005 Oct 7;310(5745):106-10 PMID: 16210539
  76. Recovery and brain reorganization after stroke in adult and aged rats.
    Ann Neurol. 2005 Dec;58(6):950-3 PMID: 16315284
  77. Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury.
    Nat Med. 2005 Dec;11(12):1355-60 PMID: 16286922
  78. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions.
    J Neurosci. 2003 Jul 2;23(13):5393-406 PMID: 12843238
  79. Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes.
    Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8999-9004 PMID: 12861073
  80. Synergistic effects of brain-derived neurotrophic factor and chondroitinase ABC on retinal fiber sprouting after denervation of the superior colliculus in adult rats.
    J Neurosci. 2003 Aug 6;23(18):7034-44 PMID: 12904464
  81. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.
    Nat Rev Neurosci. 2003 Sep;4(9):703-13 PMID: 12951563
  82. The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion.
    J Neurosci. 2003 Oct 8;23(27):9229-39 PMID: 14534257
  83. Signaling mechanisms of the myelin inhibitors of axon regeneration.
    Curr Opin Neurobiol. 2003 Oct;13(5):545-51 PMID: 14630216
  84. Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems.
    Mol Cell Neurosci. 2003 Nov;24(3):581-94 PMID: 14664809
  85. Suppression of p75NTR does not promote regeneration of injured spinal cord in mice.
    J Neurosci. 2004 Jan 14;24(2):542-6 PMID: 14724254
  86. Regeneration beyond the glial scar.
    Nat Rev Neurosci. 2004 Feb;5(2):146-56 PMID: 14735117
  87. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.
    J Neurosci. 2004 Feb 18;24(7):1646-51 PMID: 14973241
  88. PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration.
    Nat Neurosci. 2004 Mar;7(3):261-8 PMID: 14770187
  89. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.
    Nat Neurosci. 2004 Mar;7(3):221-8 PMID: 14966521
  90. Reactive astrocytes protect tissue and preserve function after spinal cord injury.
    J Neurosci. 2004 Mar 3;24(9):2143-55 PMID: 14999065
  91. Watching the neuromuscular junction.
    J Neurocytol. 2003 Jun-Sep;32(5-8):767-75 PMID: 15034266
  92. Plasticity of the spinal neural circuitry after injury.
    Annu Rev Neurosci. 2004;27:145-67 PMID: 15217329
  93. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors.
    Nature. 1990 Jan 18;343(6255):269-72 PMID: 2300171
  94. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter.
    Neuron. 1988 Mar;1(1):85-96 PMID: 3272156
  95. Molecular and cellular characterization of the glial roof plate of the spinal cord and optic tectum: a possible role for a proteoglycan in the development of an axon barrier.
    Dev Biol. 1990 Apr;138(2):359-76 PMID: 1690673
  96. Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth function.
    Neuron. 1989 Sep;3(3):377-85 PMID: 2484339
  97. Inhibition of neurite outgrowth on astroglial scars in vitro.
    J Neurosci. 1990 Nov;10(11):3594-603 PMID: 2230948
  98. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes.
    J Neurosci. 1991 Nov;11(11):3398-411 PMID: 1719160
  99. Role of intracellular calcium in NI-35-evoked collapse of neuronal growth cones.
    Science. 1993 Jan 1;259(5091):80-3 PMID: 8418499
  100. Functional characterization of chondroitin sulfate proteoglycans of brain: interactions with neurons and neural cell adhesion molecules.
    J Cell Biol. 1993 Feb;120(3):815-24 PMID: 8425902
  101. Putative inhibitory extracellular matrix molecules at the dorsal root entry zone of the spinal cord during development and after root and sciatic nerve lesions.
    Dev Biol. 1993 Mar;156(1):34-48 PMID: 7680631
  102. The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth.
    J Cell Biol. 1994 May;125(3):669-80 PMID: 7513709
  103. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration.
    Neuron. 1994 Sep;13(3):757-67 PMID: 7522484
  104. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.
    Neuron. 1994 Oct;13(4):805-11 PMID: 7524558
  105. Chondroitin sulfate proteoglycan elevates cytoplasmic calcium in DRG neurons.
    Dev Biol. 1994 Nov;166(1):87-100 PMID: 7958462
  106. Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scars.
    Exp Neurol. 1995 Nov;136(1):32-43 PMID: 7589332
  107. Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS.
    Neuron. 1995 Dec;15(6):1375-81 PMID: 8845160
  108. Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein.
    Mol Cell Neurosci. 1996 Feb;7(2):89-101 PMID: 8731478
  109. Nerve growth factor promotes regeneration of sensory axons into adult rat spinal cord.
    Exp Neurol. 1996 Aug;140(2):218-29 PMID: 8690064
  110. Identification of a neuronal cell surface receptor for a growth inhibitory chondroitin sulfate proteoglycan (NG2).
    J Neurochem. 1997 Mar;68(3):1021-30 PMID: 9048747
  111. Regeneration of adult axons in white matter tracts of the central nervous system.
    Nature. 1997 Dec 18-25;390(6661):680-3 PMID: 9414159
  112. Rho GTPases and the actin cytoskeleton.
    Science. 1998 Jan 23;279(5350):509-14 PMID: 9438836
  113. MAG and MOG enhance neurite outgrowth of embryonic mouse spinal cord neurons.
    Neuroreport. 1998 Jun 22;9(9):1987-90 PMID: 9674579
  114. In vivo regulation of axon extension and pathfinding by growth-cone calcium transients.
    Nature. 1999 Jan 28;397(6717):350-5 PMID: 9950427
  115. Neurotrophins promote regeneration of sensory axons in the adult rat spinal cord.
    Brain Res. 1999 Feb 13;818(2):431-8 PMID: 10082829
  116. Nerve growth factor-induced growth of sympathetic axons into the optic tract of mature mice is enhanced by an absence of p75NTR expression.
    J Neurobiol. 1999 Apr;39(1):51-66 PMID: 10213453
  117. Enhanced neurotrophin-induced axon growth in myelinated portions of the CNS in mice lacking the p75 neurotrophin receptor.
    J Neurosci. 1999 May 15;19(10):4155-68 PMID: 10234043
  118. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury.
    Neuron. 1999 May;23(1):83-91 PMID: 10402195
  119. Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord.
    J Neurosci. 1999 Jul 15;19(14):5810-22 PMID: 10407022
  120. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
    Science. 1999 Aug 6;285(5429):895-8 PMID: 10436159
  121. Inactivation of Rho signaling pathway promotes CNS axon regeneration.
    J Neurosci. 1999 Sep 1;19(17):7537-47 PMID: 10460260
  122. SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE.
    J Neurophysiol. 1963 Nov;26:1003-17 PMID: 14084161
  123. Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice.
    J Neurosci. 2004 Nov 10;24(45):10064-73 PMID: 15537875
  124. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.
    J Neurosci. 2004 Nov 17;24(46):10511-20 PMID: 15548666
  125. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans.
    Neuron. 2004 Dec 16;44(6):961-75 PMID: 15603739
  126. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo.
    Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1205-10 PMID: 15647357
Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-003X
DOI
10.1038/nrn1956
Published
2006-08-00
Pages
617-27
Language
English
Region
England
NLM ID
100962781
PMCID
PMC2693386
Subset
IM
Grants
NINDS NIH HHS · R01 NS050626 · United States
NINDS NIH HHS · R01 NS050626-02 · United States
NINDS NIH HHS · R01 NS051788 · United States
NINDS NIH HHS · R01 NS051788-02 · United States
External Links
PubMed source DOI: 10.1038/nrn1956 PMC Full Text View journal details
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