MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth.

Amyloid Precursor Protein Secretases Animals Animals, Newborn Aspartic Acid Endopeptidases/pharmacology Blotting, Western/methods Cells, Cultured Cerebellum/cytology Cricetinae Cricetulus Drug Interactions Endopeptidases Enzyme Activation/drug effects Enzyme Inhibitors/pharmacology Membrane Proteins/metabolism Myelin-Associated Glycoprotein/pharmacology Neural Inhibition/drug effects Neurites/drug effects,physiology Neuroblastoma Neurons/drug effects,physiology Oligopeptides/pharmacology Protein Structure, Tertiary/physiology Rats Receptor, Nerve Growth Factor Receptors, Nerve Growth Factor/chemistry,metabolism Recombinant Fusion Proteins/metabolism,pharmacology Tetradecanoylphorbol Acetate/pharmacology Transfection/methods rho GTP-Binding Proteins/metabolism

Enzyme Inhibitors Membrane Proteins Myelin-Associated Glycoprotein Oligopeptides Receptor, Nerve Growth Factor Receptors, Nerve Growth Factor Recombinant Fusion Proteins Amyloid Precursor Protein Secretases Endopeptidases Aspartic Acid Endopeptidases rho GTP-Binding Proteins Tetradecanoylphorbol Acetate epoxomicin