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PMID: 16760311 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Cyanobacterial two-component proteins: structure, diversity, distribution, and evolution.

Microbiology and molecular biology reviews : MMBR ·Vol. 70 ·No. 2 ·2006-06-00 ·Pages 472-509

Ashby MK, Houmard J

Abstract

A survey of the already characterized and potential two-component protein sequences that exist in the nine complete and seven partially annotated cyanobacterial genome sequences available (as of May 2005) showed that the cyanobacteria possess a much larger repertoire of such proteins than most other bacteria. By analysis of the domain structure of the 1,171 potential histidine kinases, response regulators, and hybrid kinases, many various arrangements of about thirty different modules could be distinguished. The number of two-component proteins is related in part to genome size but also to the variety of physiological properties and ecophysiologies of the different strains. Groups of orthologues were defined, only a few of which have representatives with known physiological functions. Based on comparisons with the proposed phylogenetic relationships between the strains, the orthology groups show that (i) a few genes, some of them clustered on the genome, have been conserved by all species, suggesting their very ancient origin and an essential role for the corresponding proteins, and (ii) duplications, fusions, gene losses, insertions, and deletions, as well as domain shuffling, occurred during evolution, leading to the extant repertoire. These mechanisms are put in perspective with the different genetic properties that cyanobacteria have to achieve genome plasticity. This review is designed to serve as a basis for orienting further research aimed at defining the most ancient regulatory mechanisms and understanding how evolution worked to select and keep the most appropriate systems for cyanobacteria to develop in the quite different environments that they have successfully colonized.

MeSH Terms
Bacterial Proteins/chemistry,genetics Cyanobacteria/chemistry,enzymology,genetics,metabolism Evolution, Molecular Genome, Bacterial Phylogeny Protein Kinases/classification,genetics,metabolism Protein Structure, Tertiary
Chemicals
Bacterial Proteins Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ashby Mark K
Department of Basic Medical Sciences, University of the West Indies, Kingston, Jamaica.
Houmard Jean
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.00046-05
Published
2006-06-00
Pages
472-509
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC1489541
Subset
IM
External Links
PubMed source DOI: 10.1128/MMBR.00046-05 PMC Full Text View journal details
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