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PMID: 16731633 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 103 ·No. 23 ·2006-06-06 ·Pages 8828-33

Brooksby B, Pogue BW, Jiang S, Dehghani H, Srinivasan S, Kogel C, Tosteson TD, Weaver J, Poplack SP, Paulsen KD

Abstract

Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

MeSH Terms
Adipose Tissue/cytology Aged Breast/cytology Female Hemoglobins/metabolism Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging/methods Middle Aged Spectroscopy, Near-Infrared/methods Tomography/methods
Chemicals
Hemoglobins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Brooksby Ben
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA.
Pogue Brian W
Jiang Shudong
Dehghani Hamid
Srinivasan Subhadra
Kogel Christine
Tosteson Tor D
Weaver John
Poplack Steven P
Paulsen Keith D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0509636103
Published
2006-06-06
Epub
2006-00-26
Pages
8828-33
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1482663
Subset
IM
Grants
NCI NIH HHS · P30 CA023108 · United States
NCI NIH HHS · R01CA69544 · United States
NCI NIH HHS · P01CA80139 · United States
NCI NIH HHS · R01 CA069544 · United States
NCI NIH HHS · P01 CA080139 · United States
External Links
PubMed source DOI: 10.1073/pnas.0509636103 PMC Full Text View journal details
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