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PMID: 10706610 Published · ppublish English Case Reports Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 6 ·2000-03-14 ·Pages 2767-72

Ntziachristos V, Yodh AG, Schnall M, Chance B

Abstract

We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam on patients scheduled for excisional biopsy or surgery so that accurate image coregistration and histopathological information of the suspicious lesions was available. The ICG-enhanced optical images coregistered accurately with Gadolinium-enhanced magnetic resonance images validating the ability of DOT to image breast tissue. In contrast to simple transillumination, we found that DOT provides for localization and quantification of exogenous tissue chromophore concentrations. Additionally our use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions.

MeSH Terms
Aged Breast Neoplasms/diagnosis Carcinoma, Ductal, Breast/diagnosis Coloring Agents Female Fibroadenoma/diagnosis Humans Indocyanine Green Magnetic Resonance Imaging/instrumentation,methods Models, Theoretical Time Factors Tomography/instrumentation,methods
Chemicals
Coloring Agents Indocyanine Green
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ntziachristos V
Departments of Bioengineering, Biochemistry/Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6089, USA. vasilis@mail.med.upenn.edu
Yodh A G
Schnall M
Chance B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.040570597
Email
vasilis@mail.med.upenn.edu
Published
2000-03-14
Pages
2767-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC16004
Subset
IM
Grants
NCI NIH HHS · R0I CA60182 · United States
NCI NIH HHS · R0I-CA75124 · United States
External Links
PubMed source DOI: 10.1073/pnas.040570597 PMC Full Text View journal details
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