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PMID: 16712 Published · ppublish English Journal Article

The immune reponse to type III pneumococcal polysaccharide in mice with malaria.

Clinical and experimental immunology ·Vol. 28 ·No. 1 ·1977-04-00 ·Pages 130-7

Wedderburn N, Dracott BN

Abstract

The immune response of BALB/c mice to type III pneumococcal polysaccharide (SIII), as measured by splenic PFC, was abolished at the height of an acute self-limiting attack of malaria caused by the murine plasmodium P. yoelii, over a wide range of antigen doses. The response to antigen, given at various times after clinical recovery, gradually reappeared, but did not reach normal levels until 12 weeks after the injection of the parasite. A second injection of P. yoelii given 1 hr before SIII caused a moderate degree of depression, although in this case the plasmodium does not multiply. In chronic malaria the response to SIII was also very poor. Short term under-nourishment was found to reduce only slightly the response to SIII.

MeSH Terms
Animals Antibody Formation Feeding Behavior Female Hemolytic Plaque Technique Malaria/immunology Mice Mice, Inbred BALB C Polysaccharides, Bacterial/immunology Streptococcus pneumoniae/immunology Time Factors
Chemicals
Polysaccharides, Bacterial
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wedderburn N
Dracott B N
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31 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1977-04-00
Pages
130-7
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1540861
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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