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PMID: 4145387 Published · ppublish English Journal Article

Regulation of the antibody response to type 3 pneumococcal polysaccharide. I. Nature of regulatory cells.

The Journal of experimental medicine ·Vol. 137 ·No. 6 ·1973-06-01 ·Pages 1431-41

Baker PJ, Reed ND, Stashak PW, Amsbaugh DF, Prescott B

Abstract

The effect of treatment with antilymphocyte serum (ALS) on the magnitude of the plaque-forming cell (PFC) response to Type III pneumococcal polysaccharide (SSS-III) was assessed in athymic nude mice and thymus-bearing littermate controls. Without ALS treatment, the PFC response was slightly higher in nude than in control mice. Treatment with ALS had no effect on the response of nude mice; however, considerable enhancement was noted in thymus-bearing controls. Such enhancement was ALS dose-dependent and demonstrable under conditions in which there was substantial inactivation of thymic-derived "helper" cells required for an antibody response to erythrocyte antigens. These findings suggest that amplifier and suppressor cells, which have been reported to regulate the magnitude of the antibody response to SSS-III, represent populations of thymic-derived cells (T cells) that are not present in nude mice. The activities of "helper" T cells and regulatory T cells appear to be independent of one another and mediated by separate subpopulations of T cells.

MeSH Terms
Animals Antibody Formation Antibody-Producing Cells Antilymphocyte Serum B-Lymphocytes/immunology Bone Marrow/immunology Bone Marrow Cells Immunity, Cellular Mice Mice, Inbred BALB C Polysaccharides, Bacterial Streptococcus pneumoniae/immunology T-Lymphocytes/immunology Viral Plaque Assay
Chemicals
Antilymphocyte Serum Polysaccharides, Bacterial
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Baker P J
Reed N D
Stashak P W
Amsbaugh D F
Prescott B
References (43)
43 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.137.6.1431
Published
1973-06-01
Pages
1431-41
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139348
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.137.6.1431 PMC Full Text View journal details
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