Home LiteratureArticle Details
PMID: 16551998 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Bone marrow diffusion measures correlate with dementia severity in HIV patients.

AJNR. American journal of neuroradiology ·Vol. 27 ·No. 3 ·2006-03-00 ·Pages 589-92

Ragin AB, Wu Y, Storey P, Cohen BA, Edelman RR, Epstein LG, Gartner S

Abstract

Escalation in monocyte trafficking from the bone marrow into the brain may play a critical role in central nervous system injury and cognitive deterioration in patients with HIV infection. This study tested the hypothesis that the mean diffusivity is sensitive to marrow changes in HIV patients and that these quantitative imaging measurements correlate with the severity of dementia. The mean diffusivity (MD), determined for clival and calvarial marrow regions, was compared in 11 HIV-infected patients and 9 control subjects. The imaging measurements were also evaluated for relationships with dementia severity and markers of disease progression (CD4 and viral load in plasma). The MD was significantly reduced in both clival and calvarial marrow in HIV-infected patients (P =.006). Diffusion measurements for clival (P =.02) and for calvarial (P =.03) regions were significantly correlated with the severity of dementia. The results of this investigation support the utility of diffusion strategies for monitoring the marrow and provide further evidence of a relationship between marrow status changes and neurologic progression in HIV patients.

MeSH Terms
AIDS Dementia Complex/pathology Bone Marrow/pathology Female HIV Seropositivity/pathology Humans Magnetic Resonance Imaging Male Middle Aged Severity of Illness Index
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Ragin A B
Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA.
Wu Y
Storey P
Cohen B A
Edelman R R
Epstein L G
Gartner S
References (27)
27 references, click to expand
  1. Reduced intravertebral bone marrow fat in HIV-infected men.
    AIDS. 2002 Jun 14;16(9):1265-9 PMID: 12045492
  2. Insights into the role of immune activation in HIV neuropathogenesis.
    J Neurovirol. 2002 Apr;8(2):69-75 PMID: 11935459
  3. MR imaging characteristics of cranial bone marrow in adult patients with underlying systemic disorders compared with healthy control subjects.
    AJNR Am J Neuroradiol. 2002 Feb;23(2):248-54 PMID: 11847050
  4. Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy.
    Arch Neurol. 2004 Nov;61(11):1687-96 PMID: 15534180
  5. HIV infection and dementia.
    Science. 2000 Jan 28;287(5453):602-4 PMID: 10691542
  6. Pathways to neuronal injury and apoptosis in HIV-associated dementia.
    Nature. 2001 Apr 19;410(6831):988-94 PMID: 11309629
  7. Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS.
    Annu Rev Neurosci. 2002;25:537-62 PMID: 12052920
  8. AIDS dementia.
    Med Clin North Am. 2002 May;86(3):537-50, vi PMID: 12168558
  9. The basis of anisotropic water diffusion in the nervous system - a technical review.
    NMR Biomed. 2002 Nov-Dec;15(7-8):435-55 PMID: 12489094
  10. Inter-rater reliability of a clinical staging of HIV-associated cognitive impairment.
    Neurology. 2003 May 13;60(9):1467-73 PMID: 12743233
  11. Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men: a 1H spectroscopic imaging study.
    Magn Reson Med. 2004 Sep;52(3):552-8 PMID: 15334574
  12. Myelodysplasia in the acquired immune deficiency syndrome.
    Am J Clin Pathol. 1985 Aug;84(2):144-52 PMID: 4025220
  13. The AIDS dementia complex.
    J Infect Dis. 1988 Nov;158(5):1079-83 PMID: 3053922
  14. The magnetic resonance hypointense spine of AIDS.
    J Comput Assist Tomogr. 1990 Sep-Oct;14(5):785-9 PMID: 2398161
  15. Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study.
    Neurology. 1993 Nov;43(11):2245-52 PMID: 8232937
  16. Comparison of bone marrow and hematologic findings in patients with human immunodeficiency virus infection and those with myelodysplastic syndromes and infectious diseases.
    Am J Clin Pathol. 1994 Feb;101(2):123-9 PMID: 8116565
  17. Ki-S1 and proliferating cell nuclear antigen expression of bone marrow macrophages. Immunohistochemical and morphometric study including reactive (inflammatory) myelitis, secondary aplastic anemia, AIDS, myelodysplastic syndromes and primary (idiopathic) osteomyelofibrosis.
    Acta Haematol. 1994;91(3):144-9 PMID: 7522384
  18. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome.
    Ann Neurol. 1994 Oct;36(4):673-6 PMID: 7944304
  19. Clival marrow changes in AIDS: findings at MR imaging.
    Radiology. 1994 Dec;193(3):623-7 PMID: 7972798
  20. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia.
    Ann Neurol. 1995 Nov;38(5):755-62 PMID: 7486867
  21. HIV type 1 RNA expression in bone marrows of patients with a spectrum of disease.
    AIDS Res Hum Retroviruses. 1996 Nov 1;12(16):1551-8 PMID: 8911581
  22. Unique monocyte subset in patients with AIDS dementia.
    Lancet. 1997 Mar 8;349(9053):692-5 PMID: 9078201
  23. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.
    Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3117-21 PMID: 9501225
  24. A simplified method to measure the diffusion tensor from seven MR images.
    Magn Reson Med. 1998 Jun;39(6):928-34 PMID: 9621916
  25. Bone marrow involvement in lymphoma: the importance of marrow magnetic resonance imaging.
    Leuk Lymphoma. 1998 May;29(5-6):515-22 PMID: 9643565
  26. Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon.
    J Biol Chem. 1999 Jun 11;274(24):17098-102 PMID: 10358063
  27. Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia.
    Ann Neurol. 1999 Sep;46(3):391-8 PMID: 10482270
Article Info
Journal
AJNR. American journal of neuroradiology
Abbr.
AJNR Am J Neuroradiol
ISSN
0195-6108
Published
2006-03-00
Pages
589-92
Language
English
Region
United States
NLM ID
8003708
PMCID
PMC2276120
Subset
IM
Grants
NIMH NIH HHS · K23 MH066705-01 · United States
NIMH NIH HHS · K23 MH066705-02S1 · United States
NIMH NIH HHS · R01 MH063039 · United States
NIMH NIH HHS · K23 MH066705-05 · United States
NIMH NIH HHS · K23 MH066705-02 · United States
NIMH NIH HHS · MH63039 · United States
NINDS NIH HHS · NS36519 · United States
NINDS NIH HHS · P01 NS036519 · United States
NINDS NIH HHS · NS049465 · United States
NIMH NIH HHS · K23 MH066705 · United States
NIMH NIH HHS · MH66705 · United States
NIMH NIH HHS · K23 MH066705-03 · United States
NIMH NIH HHS · K23 MH066705-04 · United States
NINDS NIH HHS · R01 NS049465 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2