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PMID: 11935459 Published · ppublish English Journal Article Review

Insights into the role of immune activation in HIV neuropathogenesis.

Journal of neurovirology ·Vol. 8 ·No. 2 ·2002-04-00 ·Pages 69-75

Gartner S, Liu Y

Abstract

How does HIV infection lead to the development of central nervous system disease? Central to this question is identification of the relative contributions of (1) the virus, (2) its host cells, and (3) secondary or downstream events to the pathological process. These are re-examined in this brief review. Also, a greater appreciation for the role of systemic events in neuroinflammation is emerging, with likely relevance to HIV-associated dementia. We propose here a model for HIV neuropathogenesis that highlights the role of systemic monocyte activation and subsequent neuroinvasion in initiating the disease.

MeSH Terms
AIDS Dementia Complex/etiology,immunology,pathology Brain/immunology,pathology,virology Humans Microglia/immunology,pathology,virology Monocytes/immunology,pathology,virology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gartner Suzanne
Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA. sgartner@jhmi.edu
Liu Yiling
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Article Info
Journal
Journal of neurovirology
Abbr.
J Neurovirol
ISSN
1355-0284
DOI
10.1080/13550280290049525
Email
sgartner@jhmi.edu
Published
2002-04-00
Pages
69-75
Language
English
Region
United States
NLM ID
9508123
Subset
IM
External Links
PubMed source DOI: 10.1080/13550280290049525 View journal details
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