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PMID: 8891552 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Vertical human immunodeficiency virus-1 infection: involvement of the central nervous system and treatment.

European journal of pediatrics ·Vol. 155 ·No. 10 ·1996-10-00 ·Pages 839-50

Exhenry C, Nadal D

Abstract

Involvement of the central nervous system (CNS) contributes substantially to morbidity and mortality of vertical infection with the human immunodeficiency virus (HIV)-1. The clinical spectrum ranges from minor developmental disabilities to severe and progressive encephalopathy. Progression of the disease varies considerably. Both direct viral and indirect host-related pathogenic mechanisms have been proposed. The diagnosis depends on neurological and neurodevelopmental assessments. So far, HIV-1-specific antiviral treatment has shown limited effects on neurological manifestations in symptomatic children. Thus, efforts are needed to improve prevention and treatment of CNS involvement. It is still unclear whether early use of antiretroviral agents is of benefit. Since experience of treatment of HIV-1 infections in adults cannot easily be translated to children, paediatric clinical trials are needed to answer questions specific to the unique characteristics of children.

MeSH Terms
AIDS Dementia Complex/diagnosis,etiology Acquired Immunodeficiency Syndrome/complications,drug therapy,transmission Adult Antiviral Agents/therapeutic use Atrophy Brain/pathology Central Nervous System Diseases/diagnosis,drug therapy,etiology Child Diagnosis, Differential Disease Progression HIV-1 Humans Infant Infectious Disease Transmission, Vertical Magnetic Resonance Imaging Meningitis, Aseptic/etiology Tomography, X-Ray Computed
Chemicals
Antiviral Agents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Exhenry C
Infectious Diseases Unit, University Children's Hospital of Zurich, Switzerland.
Nadal D
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Article Info
Journal
European journal of pediatrics
Abbr.
Eur J Pediatr
ISSN
0340-6199
DOI
10.1007/BF02282832
Published
1996-10-00
Pages
839-50
Language
English
Region
Germany
NLM ID
7603873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02282832 View journal details
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