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PMID: 16547610 Published · ppublish English Journal Article

Polymer chain models of DNA and chromatin.

The European physical journal. E, Soft matter ·Vol. 19 ·No. 3 ·2006-03-00 ·Pages 241-9

Langowski J

Abstract

Many properties of the genome in the cell nucleus can be understood by modeling DNA and chromatin as a flexible polymer chain. This article introduces into current models for such a coarse-grained description and reviews some recent results from our own group. Examples given are the unrolling of DNA from the histone core and the response of the 30 nm chromatin fiber to mechanical stretching.

MeSH Terms
Cell Nucleus/ultrastructure Chromatin/chemistry Computer Simulation DNA/chemistry,genetics Genome Models, Molecular Monte Carlo Method Nanostructures Nucleosomes/ultrastructure
Chemicals
Chromatin Nucleosomes DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Langowski J
Division Biophysics of Macromolecules, German Cancer Research Center, Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany. jl@dkfz-heidelberg.de
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Article Info
Journal
The European physical journal. E, Soft matter
Abbr.
Eur Phys J E Soft Matter
ISSN
1292-8941
DOI
10.1140/epje/i2005-10067-9
Email
jl@dkfz-heidelberg.de
Published
2006-03-00
Epub
2006-00-20
Pages
241-9
Language
English
Region
France
NLM ID
101126530
Subset
IM
External Links
PubMed source DOI: 10.1140/epje/i2005-10067-9 View journal details
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