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PMID: 16453568 Published · ppublish English Journal Article

The three-dimensional folding of the tRNA-like structure of tobacco mosaic virus RNA. A new building principle applied twice.

The EMBO journal ·Vol. 3 ·No. 11 ·1984-11-00 ·Pages 2613-9

Rietveld K, Linschooten K, Pleij CW, Bosch L

Abstract

The structure of the tRNA-like 3' terminus of tobacco mosaic virus (TMV) RNA has been studied. A 3' -terminal fragment possessing the tRNA-like properties was probed with chemical modification and enzymatic digestions. A model of the secondary structure is proposed for the last 105 nucleotides. The corresponding region of other tobamoviral RNAs can be folded in an identical secondary structure. A three-dimensional model for the tRNA-like structure is given which is compared with those proposed earlier for the tRNA-like 3' termini of turnip yellow mosaic virus (TYMV) RNA and brome mosaic virus (BMV) RNA. A new building principle which we discovered previously by studying the latter RNAs appears to be applied twice in the tRNA-like structure of TMV RNA. The determination of the minimal length requirement for recognition of CTP, ATP:tRNA nucleotidyl-transferase reveals a size of 100 nucleotides in agreement with the models proposed.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rietveld K
Department of Biochemistry, State University of Leiden, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands.
Linschooten K
Pleij C W
Bosch L
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-11-00
Pages
2613-9
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557738
External Links
PubMed source PMC Full Text View journal details
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