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PMID: 16405732 Published · epublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Structural and functional properties of genes involved in human cancer.

BMC genomics ·Vol. 7 ·2006-01-11 ·Pages 3

Furney SJ, Higgins DG, Ouzounis CA, López-Bigas N

Abstract

One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer. We have conducted an analysis of a set of genes known to be involved in cancer in order to unveil their unique features that can assist towards the identification of new candidate cancer genes. We have detected key patterns in this group of genes in terms of the molecular function or the biological process in which they are involved as well as sequence properties. Based on these features we have developed an accurate Bayesian classification model with which human genes have been scored for their likelihood of involvement in cancer.

MeSH Terms
Amino Acid Sequence Animals Bayes Theorem Conserved Sequence Gene Expression Regulation, Neoplastic Humans Neoplasm Proteins/chemistry,genetics Neoplasms/genetics Oligonucleotide Array Sequence Analysis Proteins/chemistry,genetics
Chemicals
Neoplasm Proteins Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Furney Simon J
Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK. simon.furney@ucd.ie
Higgins Desmond G
Ouzounis Christos A
López-Bigas Núria
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Article Info
Journal
BMC genomics
Abbr.
BMC Genomics
ISSN
1471-2164
DOI
10.1186/1471-2164-7-3
Email
simon.furney@ucd.ie
Published
2006-01-11
Epub
2006-00-11
Pages
3
Language
English
Region
England
NLM ID
100965258
PMCID
PMC1373651
Subset
IM
External Links
PubMed source DOI: 10.1186/1471-2164-7-3 PMC Full Text View journal details
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