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PMID: 16389943 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The role of angiopoietins during angiogenesis in gliomas.

Brain pathology (Zurich, Switzerland) ·Vol. 15 ·No. 4 ·2005-10-00 ·Pages 311-7

Reiss Y, Machein MR, Plate KH

Abstract

The formation of new blood vessels plays an important role in human disease development and progression. For instance, it is well established that the growth of most cancers critically depends on the supply of nutrition and oxygen by newly recruited blood vessels. Similarly, malignant gliomas, the most common primary brain tumors occurring in humans are highly dependent on angiogenesis. In recent years, there has been tremendous effort to uncover the molecular mechanisms that drive blood vessel growth in adult tissues, especially during cancer progression. Vascular endothelial growth factor (VEGF) and other morphogens, such as angiopoietins and ephrins have been shown to be critically involved in the formation of new blood vessels during both developmental and pathological angiogenesis as evidenced by genetic studies in mice. In this review, we focus on angiopoietins, a family of growth factor ligands binding to Tie tyrosine kinase receptors with emphasis on their functional consequences during the growth and progression of experimental tumors and malignant human gliomas.

MeSH Terms
Angiopoietins/metabolism Animals Brain Neoplasms/blood supply,pathology Glioma/blood supply,pathology Humans Neovascularization, Pathologic/physiopathology Neovascularization, Physiologic/physiology
Chemicals
Angiopoietins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Reiss Yvonne
Institute of Neurology/Edinger Institute, Frankfurt University Medical School, Frankfurt, Germany.
Machein Marcia R
Plate Karl H
References (69)
69 references, click to expand
  1. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
    J Biol Chem. 1999 Oct 22;274(43):30896-905 PMID: 10521483
  2. Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1.
    Br J Cancer. 2002 Feb 12;86(4):645-51 PMID: 11870550
  3. Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.
    J Biol Chem. 2004 Mar 26;279(13):13224-33 PMID: 14665640
  4. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
    Am J Pathol. 2002 Mar;160(3):985-1000 PMID: 11891196
  5. Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma.
    Am J Pathol. 2005 Mar;166(3):877-90 PMID: 15743799
  6. Increased vascularization in mice overexpressing angiopoietin-1.
    Science. 1998 Oct 16;282(5388):468-71 PMID: 9774272
  7. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway.
    J Biol Chem. 2000 Mar 31;275(13):9102-5 PMID: 10734041
  8. Angiopoietin-1 induces sprouting angiogenesis in vitro.
    Curr Biol. 1998 Apr 23;8(9):529-32 PMID: 9560344
  9. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases.
    Cancer Res. 2001 Mar 1;61(5):2145-53 PMID: 11280779
  10. The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism.
    J Cell Sci. 2005 Feb 15;118(Pt 4):771-80 PMID: 15687104
  11. Molecular mechanisms of blood vessel growth.
    Cardiovasc Res. 2001 Feb 16;49(3):507-21 PMID: 11166264
  12. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.
    Blood. 2005 Jun 15;105(12):4642-8 PMID: 15746084
  13. Expression and function of angiopoietin-1 in breast cancer.
    Br J Cancer. 2000 Nov;83(9):1154-60 PMID: 11027428
  14. Angiopoietin-1 inhibits tumour growth and ascites formation in a murine model of peritoneal carcinomatosis.
    Br J Cancer. 2002 Nov 4;87(10):1182-7 PMID: 12402160
  15. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
    Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9355-8 PMID: 8415706
  16. Openings between defective endothelial cells explain tumor vessel leakiness.
    Am J Pathol. 2000 Apr;156(4):1363-80 PMID: 10751361
  17. Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth.
    Am J Pathol. 2002 Apr;160(4):1381-92 PMID: 11943723
  18. Signaling vascular morphogenesis and maintenance.
    Science. 1997 Jul 4;277(5322):48-50 PMID: 9229772
  19. Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development.
    Dev Dyn. 1995 May;203(1):80-92 PMID: 7647376
  20. Angiopoietin-2 is implicated in the regulation of tumor angiogenesis.
    Am J Pathol. 2001 Feb;158(2):563-70 PMID: 11159193
  21. Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements.
    Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1803-9 PMID: 15284088
  22. VEGF in brain tumors.
    J Neurooncol. 2000 Oct-Nov;50(1-2):109-20 PMID: 11245271
  23. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors.
    Cancer Res. 2003 Jun 15;63(12):3370-7 PMID: 12810673
  24. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
    Science. 1997 Jul 4;277(5322):55-60 PMID: 9204896
  25. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.
    Cell. 1996 Aug 9;86(3):353-64 PMID: 8756718
  26. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.
    J Clin Invest. 1997 Oct 15;100(8):2072-8 PMID: 9329972
  27. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
    Cell. 1996 Dec 27;87(7):1171-80 PMID: 8980224
  28. Angiogenesis in malignant gliomas.
    Glia. 1995 Nov;15(3):339-47 PMID: 8586468
  29. Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice.
    Exp Cell Res. 2002 Oct 1;279(2):299-309 PMID: 12243755
  30. In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.
    Exp Neurol. 1999 Oct;159(2):391-400 PMID: 10506510
  31. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway.
    Cancer Res. 1999 Jul 1;59(13):3185-91 PMID: 10397264
  32. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene.
    Nature. 1996 Apr 4;380(6573):439-42 PMID: 8602242
  33. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.
    Nature. 1995 Jul 6;376(6535):70-4 PMID: 7596437
  34. Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.
    Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8904-9 PMID: 12861074
  35. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
    Science. 2005 Jan 7;307(5706):58-62 PMID: 15637262
  36. Neoangiogenesis in human astrocytomas: expression and functional role of angiopoietins and their cognate receptors.
    Front Biosci. 2003 Jan 01;8:e128-37 PMID: 12456344
  37. The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.
    Semin Cell Dev Biol. 2002 Feb;13(1):19-27 PMID: 11969368
  38. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells.
    J Biol Chem. 1999 May 28;274(22):15732-9 PMID: 10336473
  39. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
    Cancer Cell. 2004 Nov;6(5):507-16 PMID: 15542434
  40. Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.
    Cancer Res. 2003 Jun 15;63(12):3403-12 PMID: 12810677
  41. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis.
    Am J Pathol. 1998 Nov;153(5):1459-66 PMID: 9811337
  42. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.
    J Clin Invest. 1999 Feb;103(3):341-5 PMID: 9927494
  43. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.
    Circ Res. 1997 Oct;81(4):567-74 PMID: 9314838
  44. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions.
    Circ Res. 2000 Sep 29;87(7):603-7 PMID: 11009566
  45. Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival.
    Int J Cancer. 2003 Feb 10;103(4):466-74 PMID: 12478661
  46. Angiogenesis in cancer, vascular, rheumatoid and other disease.
    Nat Med. 1995 Jan;1(1):27-31 PMID: 7584949
  47. Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell-cell interactions requires activation of PKC beta.
    J Cell Physiol. 2004 Jan;198(1):53-61 PMID: 14584044
  48. Vascular-specific growth factors and blood vessel formation.
    Nature. 2000 Sep 14;407(6801):242-8 PMID: 11001067
  49. Angiopoietins in tumours: the angiogenic switch.
    J Pathol. 2004 Sep;204(1):1-10 PMID: 15307132
  50. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.
    Oncogene. 1993 May;8(5):1293-301 PMID: 8386827
  51. Tumor angiogenesis: therapeutic implications.
    N Engl J Med. 1971 Nov 18;285(21):1182-6 PMID: 4938153
  52. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele.
    Nature. 1996 Apr 4;380(6573):435-9 PMID: 8602241
  53. The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer.
    Cancer Res. 2001 Feb 15;61(4):1255-9 PMID: 11245414
  54. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.
    Dev Cell. 2002 Sep;3(3):411-23 PMID: 12361603
  55. Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells.
    Microvasc Res. 1999 Nov;58(3):224-37 PMID: 10527766
  56. Targeting the Tie2/Tek receptor in astrocytomas.
    Am J Pathol. 2004 Feb;164(2):467-76 PMID: 14742253
  57. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.
    Blood. 2005 Jun 15;105(12):4649-56 PMID: 15705793
  58. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.
    Mol Cell Biol. 1992 Apr;12(4):1698-707 PMID: 1312667
  59. Endothelial gaps as sites for plasma leakage in inflammation.
    Microcirculation. 1999 Mar;6(1):7-22 PMID: 10100186
  60. Mechanisms of angiogenesis.
    Nature. 1997 Apr 17;386(6626):671-4 PMID: 9109485
  61. Differential inhibition of tumor angiogenesis by tie2 and vascular endothelial growth factor receptor-2 dominant-negative receptor mutants.
    Int J Cancer. 2001 Feb 1;91(3):273-82 PMID: 11169947
  62. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma.
    Int J Oncol. 2004 Mar;24(3):539-47 PMID: 14767538
  63. Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis.
    Lab Invest. 2000 Jun;80(6):837-49 PMID: 10879735
  64. Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis.
    Cancer Res. 2001 Aug 15;61(16):6248-54 PMID: 11507079
  65. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.
    Science. 1999 Jun 18;284(5422):1994-8 PMID: 10373119
  66. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
    Cell. 1996 Dec 27;87(7):1161-9 PMID: 8980223
  67. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model.
    Am J Pathol. 2004 Nov;165(5):1557-70 PMID: 15509526
  68. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
    Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8829-34 PMID: 9671764
  69. Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage.
    Development. 1993 Nov;119(3):957-68 PMID: 8187650
Article Info
Journal
Brain pathology (Zurich, Switzerland)
Abbr.
Brain Pathol
ISSN
1015-6305
DOI
10.1111/j.1750-3639.2005.tb00116.x
Published
2005-10-00
Pages
311-7
Language
English
Region
Switzerland
NLM ID
9216781
PMCID
PMC8095963
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1750-3639.2005.tb00116.x PMC Full Text View journal details
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