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PMID: 1631156 Published · ppublish English Comparative Study Journal Article

Evolution of major histocompatibility complex class II allelic diversity: direct descent in mice and humans.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 14 ·1992-07-15 ·Pages 6545-9

Lundberg AS, McDevitt HO

Abstract

The high degree of polymorphism seen at major histocompatibility complex (MHC) class II loci is a feature unique to the MHC. Most of the beta-chain polymorphism is localized in "hypervariable" regions (HVRs). HVR amino acid sequence similarity between distantly related species has recently been found. We have employed a Monte-Carlo statistic to show that shared HVR polymorphism between beta-chain genes of humans and mice represents direct descent of ancestral sequences rather than convergent evolution. Furthermore, half the sequence polymorphism seen in class II beta-chain genes of mice persists in evolution and is encoded by the same DNA sequence in humans. No evidence for increased mutation rate within the HVR was found. We postulate that the HVR can be considered the genetic unit of recombination, with selection for HVR sequences and combinations of HVRs constrained by functional considerations.

MeSH Terms
Alleles Amino Acid Sequence Animals Base Sequence Biological Evolution Genes, MHC Class II Humans Mice Molecular Sequence Data Monte Carlo Method Polymorphism, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lundberg A S
Department of Microbiology, Stanford University Medical School, CA 94305.
McDevitt H O
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.14.6545
Published
1992-07-15
Pages
6545-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC49538
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.89.14.6545 PMC Full Text View journal details
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