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PMID: 16260739 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Innate control of adaptive immunity via remodeling of lymph node feed arteriole.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 102 ·No. 45 ·2005-11-08 ·Pages 16315-20

Soderberg KA, Payne GW, Sato A, Medzhitov R, Segal SS, Iwasaki A

Abstract

The adaptive immune system relies on rare cognate lymphocytes to detect pathogen-derived antigens. Naïve lymphocytes recirculate through secondary lymphoid organs in search of cognate antigen. Here, we show that the naïve-lymphocyte recirculation pattern is controlled at the level of innate immune recognition, independent of antigen-specific stimulation. We demonstrate that inflammation-induced lymphocyte recruitment to the lymph node is mediated by the remodeling of the primary feed arteriole, and that its physiological role is to increase the efficiency of screening for rare antigen-specific lymphocytes. Our data reveal a mechanism of innate control of adaptive immunity: by increasing the pool of naïve lymphocytes for detection of foreign antigens via regulation of vascular input to the local lymph node.

MeSH Terms
Animals Arterioles/pathology Female Hypertrophy Immunity, Innate Inflammation/pathology Lymph Nodes/blood supply,pathology Lymphatic Vessels/pathology Lymphocyte Count Lymphocytes/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Th1 Cells/immunology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Soderberg Kelly A
Section of Immunobiology, John B. Pierce Laboratory and Department of Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Payne Geoffrey W
Sato Ayuko
Medzhitov Ruslan
Segal Steven S
Iwasaki Akiko
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0506190102
Published
2005-11-08
Epub
2005-00-31
Pages
16315-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1283434
Subset
IM
Grants
NCI NIH HHS · R01 CA016885 · United States
NIAID NIH HHS · R01 AI054359 · United States
NIA NIH HHS · R21 AG19347 · United States
NIA NIH HHS · R21 AG019347 · United States
NIAID NIH HHS · R56 AI062428 · United States
NIAID NIH HHS · AI062428 · United States
NIAID NIH HHS · R01 AI062428 · United States
NCI NIH HHS · R56 CA016885 · United States
External Links
PubMed source DOI: 10.1073/pnas.0506190102 PMC Full Text View journal details
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