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PMID: 16254603 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Perspectives on human genetic variation from the HapMap Project.

PLoS genetics ·Vol. 1 ·No. 4 ·2005-10-00 ·Pages e54

McVean G, Spencer CC, Chaix R

Abstract

The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap Project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it.

MeSH Terms
Alleles Chromosome Mapping Evolution, Molecular Genetic Variation Genetics, Population Genome, Human Humans Linkage Disequilibrium Polymorphism, Single Nucleotide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McVean Gil
Department of Statistics, University of Oxford, Oxford, United Kingdom. mcvean@stats.ox.ac.uk
Spencer Chris C A
Chaix Raphaelle
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Article Info
Journal
PLoS genetics
Abbr.
PLoS Genet
ISSN
1553-7404
DOI
10.1371/journal.pgen.0010054
Email
mcvean@stats.ox.ac.uk
Published
2005-10-00
Pages
e54
Language
English
Region
United States
NLM ID
101239074
PMCID
PMC1270010
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pgen.0010054 PMC Full Text View journal details
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