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PMID: 16219791 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Extreme population-dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare.

Genetics ·Vol. 172 ·No. 1 ·2006-01-00 ·Pages 557-67

Caldwell KS, Russell J, Langridge P, Powell W

Abstract

In human genetics a detailed knowledge of linkage disequilibrium (LD) is considered a prerequisite for effective population-based, high-resolution gene mapping and cloning. Similar opportunities exist for plants; however, differences in breeding system and population history need to be considered. Here we report a detailed study of localized LD in different populations of an inbreeding crop species. We measured LD between and within four gene loci within the region surrounding the hardness locus in three different gene pools of barley (Hordeum vulgare). We demonstrate that LD extends to at least 212 kb in elite barley cultivars but is rapidly eroded in related inbreeding ancestral populations. Our results indicate that haplotype-based sequence analysis in multiple populations will provide new opportunities to adjust the resolution of association studies in inbreeding crop species.

MeSH Terms
Chromosomes, Plant Genetic Variation Genetics, Population Genome, Plant Haplotypes/genetics Hordeum/genetics Inbreeding Linkage Disequilibrium Molecular Sequence Data Polymorphism, Single Nucleotide Selection, Genetic
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Caldwell Katherine S
Scottish Crop Research Institute, Invergowrie, Dundee, Scotland.
Russell Joanne
Langridge Peter
Powell Wayne
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.104.038489
Published
2006-01-00
Epub
2005-00-11
Pages
557-67
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1456183
Subset
IM
Databases
GENBANK
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PubMed source DOI: 10.1534/genetics.104.038489 PMC Full Text View journal details
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