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LiteratureArticle Details
PMID: 12136029
Published · ppublish
English
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana.
Abstract
Arabidopsis thaliana is a highly selfing plant that nevertheless appears to undergo substantial recombination. To reconcile its selfing habit with the observations of recombination, we have sampled the genetic diversity of A. thaliana at 14 loci of approximately 500 bp each, spread across 170 kb of genomic sequence centered on a QTL for resistance to herbivory. A total of 170 of the 6321 nucleotides surveyed were polymorphic, with 169 being biallelic. The mean silent genetic diversity (pi(s)) varied between 0.001 and 0.03. Pairwise linkage disequilibria between the polymorphisms were negatively correlated with distance, although this effect vanished when only pairs of polymorphisms with four haplotypes were included in the analysis. The absence of a consistent negative correlation between distance and linkage disequilibrium indicated that gene conversion might have played an important role in distributing genetic diversity throughout the region. We tested this by coalescent simulations and estimate that up to 90% of recombination is due to gene conversion.
MeSH Terms
Arabidopsis/genetics
Base Sequence
DNA Primers
Gene Conversion
Genome, Plant
Linkage Disequilibrium
Models, Theoretical
Molecular Sequence Data
Quantitative Trait Loci
Recombination, Genetic
Chemicals
DNA Primers
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
Published
2002-07-00
Pages
1269-78
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1462186
Subset
IM
Databases
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