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PMID: 16215276 Published · ppublish English Journal Article Review

Neuronal homeostasis through translational control.

Molecular neurobiology ·Vol. 32 ·No. 2 ·2005-10-00 ·Pages 113-21

Baines RA

Abstract

Translational repression is a key component of the mechanism that establishes segment polarity during early embryonic development in the fruitfly Drosophila melanogaster. Two proteins, Pumilio (Pum) and Nanos, block the translation of hunchback messenger RNA in only the posterior segments, thereby promoting an abdominal fate. More recent studies focusing on postembryonic neuronal function have shown that Pum is also integral to numerous mechanisms that allow neurons to adapt to the changing requirements placed on them in a dynamic nervous system. These mechanisms include those contributing to dendritic structure, synaptic growth, neuronal excitability, and formation of long-term memory. This article describes these new studies and highlights the role of translational repression in regulation of neuronal processes that compensate for change.

MeSH Terms
Animals Drosophila Proteins/metabolism Drosophila melanogaster/cytology,genetics,growth & development,metabolism Homeostasis Memory/physiology Neurons/cytology,metabolism Protein Biosynthesis/genetics RNA-Binding Proteins
Chemicals
Drosophila Proteins RNA-Binding Proteins pum protein, Drosophila
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Baines Richard A
Neuroscience Group, Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom. rbaines@bio.warwick.ac.uk
References (54)
54 references, click to expand
  1. The Pumilio RNA-binding domain is also a translational regulator.
    Mol Cell. 1998 May;1(6):863-72 PMID: 9660969
  2. Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS.
    J Neurosci. 2003 Sep 24;23(25):8664-72 PMID: 14507965
  3. RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos.
    Cell. 1991 Nov 29;67(5):955-67 PMID: 1720354
  4. Synapse-specific control of synaptic efficacy at the terminals of a single neuron.
    Nature. 1998 Mar 5;392(6671):82-6 PMID: 9510251
  5. Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A.
    J Neurosci. 1997 Aug 15;17(16):6086-93 PMID: 9236220
  6. Structure of Pumilio reveals similarity between RNA and peptide binding motifs.
    Cell. 2001 Apr 20;105(2):281-9 PMID: 11336677
  7. Translational repressors in Drosophila.
    Trends Genet. 2002 Nov;18(11):572-7 PMID: 12414187
  8. Conserved role of nanos proteins in germ cell development.
    Science. 2003 Aug 29;301(5637):1239-41 PMID: 12947200
  9. Recruitment of Nanos to hunchback mRNA by Pumilio.
    Genes Dev. 1999 Oct 15;13(20):2704-12 PMID: 10541556
  10. The postsynaptic glutamate receptor subunit DGluR-IIA mediates long-term plasticity in Drosophila.
    J Neurosci. 2002 Sep 1;22(17):7362-72 PMID: 12196557
  11. The Drosophila melanogaster translational repressor pumilio regulates neuronal excitability.
    Genetics. 2002 Jul;161(3):1177-85 PMID: 12136020
  12. Translational repression: a duet of Nanos and Pumilio.
    Curr Biol. 2000 Jan 27;10(2):R81-3 PMID: 10662662
  13. The Drosophila pumilio gene: an unusually long transcription unit and an unusual protein.
    Development. 1992 Jan;114(1):221-32 PMID: 1576962
  14. Protein synthesis at synaptic sites on dendrites.
    Annu Rev Neurosci. 2001;24:299-325 PMID: 11283313
  15. Dosage effects of a Drosophila sodium channel gene on behavior and axonal excitability.
    Genetics. 1990 Jan;124(1):133-43 PMID: 2155153
  16. Molecular insights into mRNA transport and local translation in the mammalian nervous system.
    Neuron. 2000 Jan;25(1):19-28 PMID: 10707969
  17. nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development.
    Mech Dev. 2003 Jun;120(6):721-31 PMID: 12834871
  18. Altered electrical properties in Drosophila neurons developing without synaptic transmission.
    J Neurosci. 2001 Mar 1;21(5):1523-31 PMID: 11222642
  19. Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation.
    Neuron. 2002 Oct 24;36(3):507-19 PMID: 12408852
  20. Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene.
    J Neurosci. 2004 Oct 6;24(40):8695-703 PMID: 15470135
  21. Functional architecture of the mammalian retina.
    Physiol Rev. 1991 Apr;71(2):447-80 PMID: 2006220
  22. Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres.
    Nature. 1988 Mar 17;332(6161):281-4 PMID: 2450283
  23. Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.
    Blood Cells Mol Dis. 2003 Jan-Feb;30(1):55-69 PMID: 12667987
  24. Hebb and homeostasis in neuronal plasticity.
    Curr Opin Neurobiol. 2000 Jun;10(3):358-64 PMID: 10851171
  25. Altered synaptic transmission in Drosophila hyperkinetic mutants.
    J Neurogenet. 1989 Aug;5(4):215-28 PMID: 2553904
  26. The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.
    RNA. 1997 Dec;3(12):1421-33 PMID: 9404893
  27. Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo.
    Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11359-64 PMID: 11562474
  28. Translocation of RNA granules in living neurons.
    J Neurosci. 1996 Dec 15;16(24):7812-20 PMID: 8987809
  29. Compartmentalized synthesis and degradation of proteins in neurons.
    Neuron. 2003 Oct 9;40(2):347-59 PMID: 14556713
  30. Drosophila Brain Tumor is a translational repressor.
    Genes Dev. 2001 Mar 15;15(6):762-73 PMID: 11274060
  31. Maintaining the stability of neural function: a homeostatic hypothesis.
    Annu Rev Physiol. 2001;63:847-69 PMID: 11181978
  32. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions.
    Nature. 2000 Jun 29;405(6790):1062-5 PMID: 10890448
  33. PUM2, a novel murine puf protein, and its consensus RNA-binding site.
    RNA. 2001 Dec;7(12):1855-66 PMID: 11780640
  34. Plasticity in the intrinsic excitability of cortical pyramidal neurons.
    Nat Neurosci. 1999 Jun;2(6):515-20 PMID: 10448215
  35. Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion.
    Curr Biol. 2003 Apr 15;13(8):618-26 PMID: 12699617
  36. Protein synthesis in the dendrite.
    Philos Trans R Soc Lond B Biol Sci. 2002 Apr 29;357(1420):521-9 PMID: 12028789
  37. Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos.
    Genes Dev. 1992 Dec;6(12A):2312-26 PMID: 1459455
  38. Increased neuronal excitability conferred by a mutation in the Drosophila bemused gene.
    J Neurogenet. 1995 Nov;10(2):103-18 PMID: 8592271
  39. Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.
    Gene. 2002 Oct 16;299(1-2):195-204 PMID: 12459267
  40. Over the rainbow to translational control.
    Nat Struct Biol. 2001 May;8(5):387-9 PMID: 11323708
  41. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
    Neuron. 2000 Apr;26(1):13-25 PMID: 10798388
  42. Functional modulation of brain sodium channels by cAMP-dependent phosphorylation.
    Neuron. 1992 Jun;8(6):1151-9 PMID: 1319185
  43. Extreme diversity among amacrine cells: implications for function.
    Neuron. 1998 May;20(5):971-82 PMID: 9620701
  44. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling.
    Science. 1999 Oct 22;286(5440):741-6 PMID: 10531053
  45. Crystal structure of a Pumilio homology domain.
    Mol Cell. 2001 Apr;7(4):855-65 PMID: 11336708
  46. The control of dendrite development.
    Neuron. 2003 Oct 9;40(2):229-42 PMID: 14556706
  47. Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA.
    Development. 1997 Aug;124(15):3015-23 PMID: 9247343
  48. The staufen/pumilio pathway is involved in Drosophila long-term memory.
    Curr Biol. 2003 Feb 18;13(4):286-96 PMID: 12593794
  49. A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line.
    Nature. 1997 Dec 4;390(6659):477-84 PMID: 9393998
  50. Mechanisms of RNA localization and translational regulation.
    Curr Opin Genet Dev. 2000 Oct;10(5):476-88 PMID: 10980424
  51. Do-it-yourself tiling: dendritic growth in the absence of homotypic contacts.
    Neuron. 2004 Aug 19;43(4):439-40 PMID: 15312641
  52. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells.
    Dev Genes Evol. 2003 Apr;213(3):120-6 PMID: 12690449
  53. The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E.
    Neuron. 2004 Nov 18;44(4):663-76 PMID: 15541314
  54. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.
    Curr Biol. 2004 Feb 17;14(4):314-21 PMID: 14972682
Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1385/MN:32:2:113
Email
rbaines@bio.warwick.ac.uk
Published
2005-10-00
Pages
113-21
Language
English
Region
United States
NLM ID
8900963
Subset
IM
External Links
PubMed source DOI: 10.1385/MN:32:2:113 View journal details
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