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PMID: 16200197 Published · ppublish English Journal Article Review

Mitochondria: pharmacological manipulation of cell death.

The Journal of clinical investigation ·Vol. 115 ·No. 10 ·2005-10-00 ·Pages 2640-7

Bouchier-Hayes L, Lartigue L, Newmeyer DD

Abstract

Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.

MeSH Terms
Animals Apoptosis/drug effects,physiology Cell Membrane Permeability/drug effects,physiology Drug Design Humans Mitochondria/drug effects,metabolism Pharmaceutical Preparations/metabolism Signal Transduction/drug effects,physiology
Chemicals
Pharmaceutical Preparations
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bouchier-Hayes Lisa
La Jolla Institute for Allergy and Immunology, Department of Cellular Immunology, San Diego, California 92121, USA.
Lartigue Lydia
Newmeyer Donald D
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI26274
Published
2005-10-00
Pages
2640-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1236694
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI26274 PMC Full Text View journal details
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