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PMID: 16170216 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The ERK cascade: a prototype of MAPK signaling.

Molecular biotechnology ·Vol. 31 ·No. 2 ·2005-10-00 ·Pages 151-74

Rubinfeld H, Seger R

Abstract

Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK) cascades is a common mechanism of signal transduction in many cellular processes. Four such cascades have been elucidated thus far, and named according to their MAPK tier component as the ERK1/2, JNK, p38MAPK, and ERK5 cascades. These cascades cooperate in transmitting various extracellular signals, and thus control cellular processes such as proliferation, differentiation, development, stress response, and apoptosis. Here we describe the classic ERK1/2 cascade, and concentrate mainly on the properties of MEK1/2 and ERK1/2, including their mode of regulation and their role in various cellular processes and in oncogenesis. This cascade may serve as a prototype of the other MAPK cascades, and the study of this cascade is likely to contribute to the understanding of mitogenic and other processes in many cell lines and tissues.

MeSH Terms
Animals Cell Cycle Enzyme Activation Extracellular Signal-Regulated MAP Kinases/chemistry,metabolism Humans MAP Kinase Signaling System Protein Conformation Substrate Specificity
Chemicals
Extracellular Signal-Regulated MAP Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rubinfeld Hadara
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Seger Rony
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Article Info
Journal
Molecular biotechnology
Abbr.
Mol Biotechnol
ISSN
1073-6085
DOI
10.1385/MB:31:2:151
Published
2005-10-00
Pages
151-74
Language
English
Region
United States
NLM ID
9423533
Subset
IM
External Links
PubMed source DOI: 10.1385/MB:31:2:151 View journal details
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