Stopping and going with p27kip1.

Developmental cell ·Vol. 6 ·No. 4 ·2004-04-00 ·Pages 458-9

Assoian RK

Abstract

Nuclear p27kip1 is an established inhibitor of cyclin-dependent kinase-2, and it now appears that cytoplasmic p27kip1 inhibits the activation of RhoA. In this dual role, p27kip1 could coordinate cell cycle progression and cell migration.

MeSH Terms

Animals CDC2-CDC28 Kinases/antagonists & inhibitors,genetics,metabolism Cell Cycle/genetics Cell Cycle Proteins/genetics,metabolism Cell Movement/genetics Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases/genetics,metabolism Feedback, Physiological/genetics Humans Proto-Oncogene Proteins Tumor Suppressor Proteins/genetics,metabolism rhoA GTP-Binding Protein/antagonists & inhibitors,genetics,metabolism

Chemicals

Cell Cycle Proteins Proto-Oncogene Proteins Tumor Suppressor Proteins Cyclin-Dependent Kinase Inhibitor p27 CDC2-CDC28 Kinases CDK2 protein, human CDK4 protein, human Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases rhoA GTP-Binding Protein

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Assoian Richard K

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1534-5807

DOI

10.1016/s1534-5807(04)00103-0

Published

2004-04-00

Pages

458-9

Language

English

Region

United States

NLM ID

101120028

Subset

External Links

PubMed source DOI: 10.1016/s1534-5807(04)00103-0 View journal details

Analysis Services

Stopping and going with p27kip1.

Contact

WeChat Official Account