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PMID: 16113679 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.

Nature cell biology ·Vol. 7 ·No. 9 ·2005-09-00 ·Pages 870-9

Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G

Abstract

The microvasculature consists of endothelial cells and their surrounding pericytes. Few studies on the regulatory mechanisms of tumour angiogenesis have focused on pericytes. Here we report the identification of tumour-derived PDGFRbeta (+) (platelet-derived growth factor receptor beta) progenitor perivascular cells (PPCs) that have the ability to differentiate into pericytes and regulate vessel stability and vascular survival in tumours. A subset of PDGFRbeta (+) PPCs is recruited from bone marrow to perivascular sites in tumours. Specific inhibition of PDGFRbeta signalling eliminates PDGFRbeta (+) PPCs and mature pericytes around tumour vessels, leading to vascular hyperdilation and endothelial cell apoptosis in pancreatic islet tumours of transgenic Rip1Tag2 mice.

MeSH Terms
Animals Apoptosis/physiology Blood Vessels/growth & development,metabolism,physiopathology Bone Marrow Cells/cytology,metabolism Cell Communication/physiology Cell Differentiation/physiology Cell Movement/physiology Cell Survival/physiology Coculture Techniques Endothelial Cells/physiology Female Insulinoma/blood supply,metabolism,physiopathology Male Mice Mice, Transgenic Neoplasms/blood supply,metabolism,physiopathology Neovascularization, Pathologic/metabolism,physiopathology Pancreatic Neoplasms/blood supply,metabolism,physiopathology Pericytes/cytology,metabolism Receptor, Platelet-Derived Growth Factor beta/metabolism Stem Cells/cytology,metabolism Tumor Cells, Cultured
Chemicals
Receptor, Platelet-Derived Growth Factor beta
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Song Steven
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Ewald Andrew J
Stallcup William
Werb Zena
Bergers Gabriele
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Article Info
Journal
Nature cell biology
Abbr.
Nat Cell Biol
ISSN
1465-7392
DOI
10.1038/ncb1288
Published
2005-09-00
Epub
2005-00-21
Pages
870-9
Language
English
Region
England
NLM ID
100890575
PMCID
PMC2771163
Subset
IM
Grants
NCI NIH HHS · R01 CA099948 · United States
NCI NIH HHS · R01 CA095287-05 · United States
NCI NIH HHS · R01 CA109390-01 · United States
NCI NIH HHS · P01 CA072006-07 · United States
NCI NIH HHS · R01 CA095287 · United States
NHLBI NIH HHS · 5T32HL007731 · United States
NCI NIH HHS · R01 CA99948 · United States
NCI NIH HHS · R01 CA109390 · United States
NHLBI NIH HHS · T32 HL007731 · United States
NCI NIH HHS · P01 CA072006 · United States
NCI NIH HHS · P01 CA72006 · United States
NCI NIH HHS · R01 CA95287 · United States
External Links
PubMed source DOI: 10.1038/ncb1288 PMC Full Text View journal details
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