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PMID: 16096639 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.

The EMBO journal ·Vol. 24 ·No. 17 ·2005-09-07 ·Pages 3128-35

Miller KM, Ferreira MG, Cooper JP

Abstract

Telomere protection and maintenance are accomplished through the coordinated actions of telomere-specific DNA binding proteins and their interacting partners. The fission yeast ortholog of human TRF1/2, Taz1, binds telomeric DNA and regulates numerous aspects of telomere function. Here, we ask which aspects of Taz1 function are mediated through its interacting proteins, Rap1 and Rif1. We demonstrate that rap1+ deletion phenocopies some, but not all, aspects of taz1Delta telomere dysfunction, while Rif1 exhibits a very different functional spectrum. Rap1 acts in a Taz1-dependent pathway to prevent chromosome end fusions and regulate telomeric 3' overhang formation, while Rif1 is dispensable for these functions. Telomerase inhibition by Taz1 is mediated by two separate pathways, one involving Rap1 and the other involving Rif1. In contrast, Taz1 is uniquely required to prevent chromosomal entanglements and missegregation at cold temperatures. Strikingly, while rap1+ deletion exacerbates the cold sensitivity of taz1Delta cells, rif1+ deletion restores full viability. Thus, Rap1 and Rif1 are each required for a subset of the functions of Taz1, but each acquires Taz1-independent functions in its absence. Furthermore, Taz1 can function independently of its known binding partners.

MeSH Terms
Cell Survival Chromosomes, Fungal/genetics Mutation Protein Binding Schizosaccharomyces/genetics,physiology Schizosaccharomyces pombe Proteins/genetics,metabolism Telomere/genetics,physiology Telomere-Binding Proteins/genetics,metabolism Transcription Factors/genetics,metabolism
Chemicals
Schizosaccharomyces pombe Proteins Telomere-Binding Proteins Transcription Factors taz1 protein, S pombe
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Miller Kyle M
Cancer Research UK, London Research Institute, London, UK.
Ferreira Miguel Godinho
Cooper Julia Promisel
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
2005-09-07
Epub
2005-00-11
Pages
3128-35
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1201358
Subset
IM
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