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PMID: 16086015 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Intragenic tandem repeats generate functional variability.

Nature genetics ·Vol. 37 ·No. 9 ·2005-09-00 ·Pages 986-90

Verstrepen KJ, Jansen A, Lewitter F, Fink GR

Abstract

Tandemly repeated DNA sequences are highly dynamic components of genomes. Most repeats are in intergenic regions, but some are in coding sequences or pseudogenes. In humans, expansion of intragenic triplet repeats is associated with various diseases, including Huntington chorea and fragile X syndrome. The persistence of intragenic repeats in genomes suggests that there is a compensating benefit. Here we show that in the genome of Saccharomyces cerevisiae, most genes containing intragenic repeats encode cell-wall proteins. The repeats trigger frequent recombination events in the gene or between the gene and a pseudogene, causing expansion and contraction in the gene size. This size variation creates quantitative alterations in phenotypes (e.g., adhesion, flocculation or biofilm formation). We propose that variation in intragenic repeat number provides the functional diversity of cell surface antigens that, in fungi and other pathogens, allows rapid adaptation to the environment and elusion of the host immune system.

MeSH Terms
Antigens, Surface/physiology Genes, Fungal Genetic Variation Genome, Fungal Molecular Sequence Data Phenotype Recombination, Genetic Saccharomyces cerevisiae/genetics Tandem Repeat Sequences
Chemicals
Antigens, Surface
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Verstrepen Kevin J
Whitehead Institute for Biomedical Research/Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
Jansen An
Lewitter Fran
Fink Gerald R
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
Published
2005-09-00
Epub
2005-00-07
Pages
986-90
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC1462868
Subset
IM
Grants
NIGMS NIH HHS · R01 GM035010 · United States
Databases
GENBANK
AY949845, AY949846, AY949847, AY949848, DQ029324, DQ029325
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