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PMID: 16041540 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Characterization of a C3-like cDNA in a coral: phylogenetic implications.

Immunogenetics ·Vol. 57 ·No. 7 ·2005-08-00 ·Pages 535-48

Dishaw LJ, Smith SL, Bigger CH

Abstract

C3, C4, and C5 are thiolester-containing proteins (TEPs) of vertebrate complement. The identification of the molecular origin of the TEP family, and more specifically the ancestor protein of complement components C3, C4, and C5, remains a fundamental question. The prevailing paradigm suggests that duplication and divergence of these proteins occurred after the deuterostome split in phylogeny. It is believed that the ancestor of thiolester-containing complement proteins was alpha-2-macroglobulin (A2M)-like, a noncomplement-related protein. Here we describe a C3-like cDNA from a gorgonian coral, Swiftia exserta. This study provides evidence for the origins of a complement-related C3-like gene in the Precambrian period, predating both protostomes and deuterostomes. Furthermore, one may speculate that complement-like opsonic reactions were evolving at the earliest stages of metazoan evolution. This calls for a reassessment of the present concepts concerning the origins and evolution of TEPs.

MeSH Terms
Amino Acid Sequence Animals Anthozoa/genetics,immunology Base Sequence Cloning, Molecular Complement C3/genetics Complement System Proteins/genetics DNA, Complementary/genetics Evolution, Molecular Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid Species Specificity
Chemicals
Complement C3 DNA, Complementary Complement System Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dishaw Larry J
Department of Biological Sciences, Florida International University, University Park Campus, 11200 SW 8th Street, Miami, FL 33199, USA.
Smith Sylvia L
Bigger Charles H
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/s00251-005-0005-1
Published
2005-08-00
Epub
2005-00-29
Pages
535-48
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/s00251-005-0005-1 View journal details
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