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PMID: 16024723 Published · ppublish English Comparative Study Journal Article

Yeast prions [URE3] and [PSI+] are diseases.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 102 ·No. 30 ·2005-07-26 ·Pages 10575-80

Nakayashiki T, Kurtzman CP, Edskes HK, Wickner RB

Abstract

Viruses, plasmids, and prions can spread in nature despite being a burden to their hosts. Because a prion arises de novo in more than one in 10(6) yeast cells and spreads to all offspring in meiosis, its absence in wild strains would imply that it has a net deleterious effect on its host. Among 70 wild Saccharomyces strains, we found the [PIN+] prion in 11 strains, but the [URE3] and [PSI+] prions were uniformly absent. In contrast, the "selfish" 2mu DNA was in 38 wild strains and the selfish RNA replicons L-BC, 20S, and 23S were found in 8, 14, and 1 strains, respectively. The absence of [URE3] and [PSI+] in wild strains indicates that each prion has a net deleterious effect on its host.

MeSH Terms
Glutathione Peroxidase Green Fluorescent Proteins Oligonucleotides Peptide Termination Factors Plasmids/genetics Prions/genetics Replicon/genetics Saccharomyces/genetics Saccharomyces cerevisiae Proteins/genetics Species Specificity
Chemicals
Oligonucleotides Peptide Termination Factors Prions SUP35 protein, S cerevisiae Saccharomyces cerevisiae Proteins Green Fluorescent Proteins Glutathione Peroxidase URE2 protein, S cerevisiae
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nakayashiki Toru
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 225, Bethesda, MD 20892-0830, USA.
Kurtzman Cletus P
Edskes Herman K
Wickner Reed B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0504882102
Published
2005-07-26
Epub
2005-00-15
Pages
10575-80
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1180808
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0504882102 PMC Full Text View journal details
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