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PMID: 8013903 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.

Genetics ·Vol. 136 ·No. 4 ·1994-04-00 ·Pages 1261-9

McCusker JH, Clemons KV, Stevens DA, Davis RW

Abstract

Saccharomyces cerevisiae isolates from human patients have been genetically analyzed. Some of the characteristics of these isolates are very different from laboratory and industrial strains of S. cerevisiae and, for this reason, stringent genetic tests have been used to confirm their identity as S. cerevisiae. Most of these clinical isolates are able to grow at 42 degrees, a temperature that completely inhibits the growth of most other S. cerevisiae strains. This property can be considered a virulence trait and may help explain the presence of these isolates in human hosts. The ability to grow at 42 degrees is shown to be polygenic with primarily additive effects between loci. S. cerevisiae will be a useful model for the evolution and genetic analysis of fungal virulence and the study of polygenic traits.

MeSH Terms

Crosses, Genetic Humans Saccharomyces cerevisiae/genetics,growth & development,isolation & purification,pathogenicity Temperature Virulence/genetics

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

McCusker J H

Department of Biochemistry, Stanford University School of Medicine, California 94305.

Clemons K V

Stevens D A

Davis R W

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Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/136.4.1261

Published

1994-04-00

Pages

1261-9

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1205906

Subset

Grants

NIAID NIH HHS · AI 27076 · United States

External Links

PubMed source DOI: 10.1093/genetics/136.4.1261 PMC Full Text View journal details

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Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.

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