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PMID: 15965256 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Gene arrays at Pneumocystis carinii telomeres.

Genetics ·Vol. 170 ·No. 4 ·2005-08-00 ·Pages 1589-600

Keely SP, Renauld H, Wakefield AE, Cushion MT, Smulian AG, Fosker N, Fraser A, Harris D, Murphy L, Price C, Quail MA, Seeger K, Sharp S, Tindal CJ, Warren T, Zuiderwijk E, Barrell BG, Stringer JR, Hall N

Abstract

In the fungus Pneumocystis carinii, at least three gene families (PRT1, MSR, and MSG) have the potential to generate high-frequency antigenic variation, which is likely to be a strategy by which this parasitic fungus is able to prolong its survival in the rat lung. Members of these gene families are clustered at chromosome termini, a location that fosters recombination, which has been implicated in selective expression of MSG genes. To gain insight into the architecture, evolution, and regulation of these gene clusters, six telomeric segments of the genome were sequenced. Each of the segments began with one or more unique genes, after which were members of different gene families, arranged in a head-to-tail array. The three-gene repeat PRT1-MSR-MSG was common, suggesting that duplications of these repeats have contributed to expansion of all three families. However, members of a gene family in an array were no more similar to one another than to members in other arrays, indicating rapid divergence after duplication. The intergenic spacers were more conserved than the genes and contained sequence motifs also present in subtelomeres, which in other species have been implicated in gene expression and recombination. Long mononucleotide tracts were present in some MSR genes. These unstable sequences can be expected to suffer frequent frameshift mutations, providing P. carinii with another mechanism to generate antigen variation.

MeSH Terms
Amino Acid Sequence Antigens, Fungal Base Sequence Chromosome Mapping Chromosomes, Fungal Cloning, Molecular Cosmids DNA, Fungal Evolution, Molecular Gene Duplication Gene Expression Regulation, Fungal Gene Library Genes, Fungal Genetic Linkage Genome, Fungal Open Reading Frames Pneumocystis carinii/genetics RNA, Messenger/genetics Recombination, Genetic Repetitive Sequences, Nucleic Acid Selection, Genetic Sequence Analysis, DNA Sequence Homology, Nucleic Acid Telomere/genetics
Chemicals
Antigens, Fungal DNA, Fungal RNA, Messenger
Authors & Affiliations
19 authors, click to expand affiliations / ORCID
Keely Scott P
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA.
Renauld Hubert
Wakefield Ann E
Cushion Melanie T
Smulian A George
Fosker Nigel
Fraser Audrey
Harris David
Murphy Lee
Price Claire
Quail Michael A
Seeger Kathy
Sharp Sarah
Tindal Carolyn J
Warren Tim
Zuiderwijk Eduard
Barrell Barclay G
Stringer James R
Hall Neil
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
Published
2005-08-00
Epub
2005-00-18
Pages
1589-600
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1449779
Subset
IM
Grants
NIAID NIH HHS · R01AI36701 · United States
NIAID NIH HHS · R01 AI044651 · United States
FIC NIH HHS · TW01200-02 · United States
NIAID NIH HHS · R01AI44651 · United States
NIAID NIH HHS · R01 AI036701 · United States
FIC NIH HHS · R03 TW001200 · United States
Wellcome Trust · United Kingdom
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