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PMID: 15952033 Published · ppublish English Journal Article Review

TRPV4 as osmosensor: a transgenic approach.

Pflugers Archiv : European journal of physiology ·Vol. 451 ·No. 1 ·2005-10-00 ·Pages 176-80

Liedtke W

Abstract

The transient receptor potential vanilloid 4 (TRPV4) ion channel was named initially vanilloid-receptor-related osmotically activated channel (VR-OAC). Preliminary answers to the question, "What is the function of the trpv4 gene in live animals ?" are highlighted briefly in this review. In trpv4 null mice, TRPV4 is necessary for the maintenance of osmotic equilibrium, and in Caenorhabditis elegans transgenic for mammalian TRPV4, TRPV4 directs the osmotic avoidance response in the context of the ASH "nociceptive" neuron. The molecular mechanisms of gating of TRPV4 in vivo need to be determined; in particular, whether TRPV4 in live animals is gated via phosphorylation of defined amino-acid residues or more directly through the osmotic stimulus itself.

MeSH Terms
Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins/physiology Mice Nerve Tissue Proteins/physiology Signal Transduction/physiology TRPV Cation Channels/physiology Transient Receptor Potential Channels/physiology
Chemicals
Caenorhabditis elegans Proteins Nerve Tissue Proteins OSM-9 protein, C elegans TRPV Cation Channels Transient Receptor Potential Channels Trpv4 protein, mouse
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Liedtke Wolfgang
Center for Translational Neuroscience, Duke University Medical Center, Box 2900, Durham, NC 27710, USA. wolfgang@neuro.duke.edu
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/s00424-005-1449-8
Email
wolfgang@neuro.duke.edu
Published
2005-10-00
Epub
2005-00-11
Pages
176-80
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/s00424-005-1449-8 View journal details
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