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PMID: 15928206 Published · ppublish English Journal Article Review

Cilia and the cell cycle?

The Journal of cell biology ·Vol. 169 ·No. 5 ·2005-06-06 ·Pages 707-10

Quarmby LM, Parker JD

Abstract

A recent convergence of data indicating a relationship between cilia and proliferative diseases, such as polycystic kidney disease, has revived the long-standing enigma of the reciprocal regulatory relationship between cilia and the cell cycle. Multiple signaling pathways are localized to cilia in mammalian cells, and some proteins have been shown to act both in the cilium and in cell cycle regulation. Work from the unicellular alga Chlamydomonas is providing novel insights as to how cilia and the cell cycle are coordinately regulated.

MeSH Terms
Animals Cell Cycle/physiology Cell Cycle Proteins/metabolism Chlamydomonas/metabolism Cilia/physiology Humans Phosphotransferases/metabolism Polycystic Kidney Diseases/metabolism,physiopathology Signal Transduction/physiology
Chemicals
Cell Cycle Proteins Phosphotransferases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Quarmby Lynne M
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada. Quarmby@sfu.ca
Parker Jeremy D K
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200503053
Email
quarmby@sfu.ca
Published
2005-06-06
Epub
2005-00-31
Pages
707-10
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2171619
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.200503053 PMC Full Text View journal details
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