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PMID: 15854229 Published · epublish English Journal Article Review

Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL).

Retrovirology ·Vol. 2 ·2005-04-26 ·Pages 27

Matsuoka M

Abstract

The clinical entity of adult T-cell leukemia (ATL) was established around 1977, and human T-cell leukemia virus type 1 (HTLV-I) was subsequently identified in 1980. In the 25 years since the discovery of HTLV-I, HTLV-I infection and its associated diseases have been extensively studied, and many of their aspects have been clarified. However, the detailed mechanism of leukemogenesis remains unsolved yet, and the prognosis of ATL patients still poor because of its resistance to chemotherapy and immunodeficiency. In this review, I highlight the recent progress and remaining enigmas in HTLV-I infection and its associated diseases, especially ATL.

MeSH Terms
Adult Female Human T-lymphotropic virus 1/genetics,pathogenicity,physiology Humans Infant, Newborn Leukemia-Lymphoma, Adult T-Cell/immunology,physiopathology,transmission,virology Virus Replication
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Matsuoka Masao
Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. mmatsuok@virus.kyoto-u.ac.jp
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Article Info
Journal
Retrovirology
Abbr.
Retrovirology
ISSN
1742-4690
DOI
10.1186/1742-4690-2-27
Email
mmatsuok@virus.kyoto-u.ac.jp
Published
2005-04-26
Epub
2005-00-26
Pages
27
Language
English
Region
England
NLM ID
101216893
PMCID
PMC1131926
Subset
IM
External Links
PubMed source DOI: 10.1186/1742-4690-2-27 PMC Full Text View journal details
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