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PMID: 15781691 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Saccharomyces cerevisiae histone H2A Ser122 facilitates DNA repair.

Genetics ·Vol. 170 ·No. 2 ·2005-06-00 ·Pages 543-53

Harvey AC, Jackson SP, Downs JA

Abstract

DNA repair takes place in the context of chromatin. Recently, it has become apparent that proteins that make up and modulate chromatin structure are involved in the detection and repair of DNA lesions. We previously demonstrated that Ser129 in the carboxyl-terminal tail of yeast histone H2A is important for double-strand-break responses. By undertaking a systematic site-directed mutagenesis approach, we identified another histone H2A serine residue (Ser122) that is important for survival in the presence of DNA-damaging agents. We show that mutation of this residue does not affect DNA damage-dependent Rad53 phosphorylation or G(2)/M checkpoint responses. Interestingly, we find that yeast lacking H2A S122 are defective in their ability to sporulate. Finally, we demonstrate that H2A S122 provides a function distinct from that of H2A S129. These data demonstrate a role for H2A S122 in facilitating survival in the presence of DNA damage and suggest a potential role in mediating homologous recombination. The distinct roles of H2A S122 and S129 in mediating these responses suggest that chromatin components can provide specialized functions for distinct DNA repair and survival mechanisms and point toward the possibility of a complex DNA damage responsive histone code.

MeSH Terms
Amino Acid Sequence Blotting, Western Cell Cycle Proteins/metabolism Cell Division Checkpoint Kinase 2 Chromatin/metabolism Chromatin Immunoprecipitation DNA Repair G2 Phase Histones/chemistry,genetics,metabolism Micrococcal Nuclease/metabolism Molecular Sequence Data Mutation Phosphorylation Protein Serine-Threonine Kinases/metabolism Protein Structure, Tertiary Saccharomyces cerevisiae/genetics Saccharomyces cerevisiae Proteins/metabolism Sequence Homology, Amino Acid Serine/chemistry Time Factors
Chemicals
Cell Cycle Proteins Chromatin Histones Saccharomyces cerevisiae Proteins Serine Checkpoint Kinase 2 Protein Serine-Threonine Kinases RAD53 protein, S cerevisiae Micrococcal Nuclease
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Harvey Anne C
Department of Biochemistry, University of Cambridge, UK.
Jackson Stephen P
Downs Jessica A
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31 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
Published
2005-06-00
Epub
2005-00-21
Pages
543-53
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1450416
Subset
IM
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