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PMID: 15752430 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2.

BMC cell biology ·Vol. 6 ·No. 1 ·2005-03-07 ·Pages 11

Stovold CF, Millard TH, Machesky LM

Abstract

The Scar/WAVE family of proteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterised as major regulators of lamellipodia formation downstream of Rac activation and as members of large protein complexes. We have investigated the interactions of the three human Scar/WAVE isoforms with several previously described binding partners for Scar/WAVE 1 or 2. We find that all three Scar/WAVE isoforms behave similarly and are likely to participate in the same kinds of protein complexes that regulate actin assembly. Differences between Scar/WAVE proteins are therefore likely to be at the level of tissue distribution or subtle differences in the affinity for specific binding partners.

MeSH Terms
Actins/metabolism Animals Brain Mice Multiprotein Complexes/chemistry Protein Binding Two-Hybrid System Techniques Wiskott-Aldrich Syndrome Protein Family/metabolism
Chemicals
Actins Multiprotein Complexes WASF1 protein, human WASF2 protein, human WASF3 protein, human Wiskott-Aldrich Syndrome Protein Family
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stovold Craig F
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. craig_stovold@hotmail.com <craig_stovold@hotmail.com>
Millard Thomas H
Machesky Laura M
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Article Info
Journal
BMC cell biology
Abbr.
BMC Cell Biol
ISSN
1471-2121
DOI
10.1186/1471-2121-6-11
Email
craig_stovold@hotmail.com
Published
2005-03-07
Epub
2005-00-07
Pages
11
Language
English
Region
England
NLM ID
100966972
PMCID
PMC555569
Subset
IM
Grants
Medical Research Council · G117/379 · United Kingdom
External Links
PubMed source DOI: 10.1186/1471-2121-6-11 PMC Full Text View journal details
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