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PMID: 15705323 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic background of Escherichia coli and extended-spectrum beta-lactamase type.

Emerging infectious diseases ·Vol. 11 ·No. 1 ·2005-01-00 ·Pages 54-61

Branger C, Zamfir O, Geoffroy S, Laurans G, Arlet G, Thien HV, Gouriou S, Picard B, Denamur E

Abstract

To assess the implication of the genetic background of Escherichia coli strains in the emergence of extended-spectrum-Beta -lactamases (ESBL), 55 TEM-, 52 CTX-M-, and 22 SHV-type ESBL-producing clinical isolates involved in various extraintestinal infections or colonization were studied in terms of phylogenetic group, virulence factor (VF) content (pap, sfa/foc, hly, and aer genes), and fluoroquinolone resistance. A factorial analysis of correspondence showed that SHV type, and to a lesser extent TEM type, were preferentially observed in B2 phylogenetic group strains that exhibited numerous VFs but were fluoroquinolone-susceptible, whereas the newly emerged CTX-M type was associated with the D phylogenetic group strains that lacked VF but were fluoroquinolone-resistant. Thus, the emergence of ESBL-producing E. coli seems to be the result of complex interactions between the type of ESBL, genetic background of the strain, and selective pressures in ecologic niches.

MeSH Terms
Anti-Bacterial Agents/pharmacology Ciprofloxacin/pharmacology Communicable Diseases, Emerging/microbiology Drug Resistance, Bacterial Escherichia coli/drug effects,enzymology,genetics,pathogenicity Escherichia coli Infections/microbiology Escherichia coli Proteins/genetics,metabolism Fluoroquinolones/pharmacology Humans Microbial Sensitivity Tests Phylogeny Polymerase Chain Reaction Virulence Virulence Factors/genetics,metabolism beta-Lactamases/classification,genetics,metabolism
Chemicals
Anti-Bacterial Agents Escherichia coli Proteins Fluoroquinolones Virulence Factors Ciprofloxacin beta-Lactamases
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Branger Catherine
Laboratoire de Microbiologie, Hôpital Louis Mourier, AP-HP, 178 Rue des Renouillers, 92701 Colombes Cedex, France. catherine.branger@lmr.ap-hop-paris.fr
Zamfir Oana
Geoffroy Sabine
Laurans Geneviève
Arlet Guillaume
Thien Hoang Vu
Gouriou Stéphanie
Picard Bertrand
Denamur Erick
References (39)
39 references, click to expand
  1. Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise.
    J Infect Dis. 2000 Jan;181(1):261-72 PMID: 10608775
  2. The link between phylogeny and virulence in Escherichia coli extraintestinal infection.
    Infect Immun. 1999 Feb;67(2):546-53 PMID: 9916057
  3. Rapid and simple determination of the Escherichia coli phylogenetic group.
    Appl Environ Microbiol. 2000 Oct;66(10):4555-8 PMID: 11010916
  4. Mutator natural Escherichia coli isolates have an unusual virulence phenotype.
    Infect Immun. 2001 Jan;69(1):9-14 PMID: 11119483
  5. Phylogenetic distribution of extraintestinal virulence-associated traits in Escherichia coli.
    J Infect Dis. 2001 Jan 1;183(1):78-88 PMID: 11106538
  6. TEM-24 extended-spectrum beta-lactamase-producing Enterobacter aerogenes: long-term clonal dissemination in French hospitals.
    Clin Microbiol Infect. 2000 Jun;6(6):316-23 PMID: 11168140
  7. Variations in the prevalence of strains expressing an extended-spectrum beta-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region.
    Clin Infect Dis. 2001 May 15;32 Suppl 2:S94-103 PMID: 11320450
  8. Commensal Escherichia coli isolates are phylogenetically distributed among geographically distinct human populations.
    Microbiology. 2001 Jun;147(Pt 6):1671-6 PMID: 11390698
  9. Ongoing horizontal and vertical transmission of virulence genes and papA alleles among Escherichia coli blood isolates from patients with diverse-source bacteremia.
    Infect Immun. 2001 Sep;69(9):5363-74 PMID: 11500406
  10. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.
    Clin Microbiol Rev. 2001 Oct;14(4):933-51, table of contents PMID: 11585791
  11. Decreased invasive capacity of quinolone-resistant Escherichia coli in patients with urinary tract infections.
    Clin Infect Dis. 2001 Nov 15;33(10):1682-6 PMID: 11595990
  12. Evolution and epidemiology of extended-spectrum beta-lactamases (ESBLs) and ESBL-producing microorganisms.
    Clin Microbiol Infect. 2001 Nov;7(11):597-608 PMID: 11737084
  13. Extended-spectrum beta-lactamases: the European experience.
    Curr Opin Infect Dis. 2001 Dec;14(6):697-701 PMID: 11964887
  14. Diversity of CTX-M beta-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals.
    FEMS Microbiol Lett. 2002 Apr 9;209(2):161-8 PMID: 12007800
  15. Phylogenetic analysis and prevalence of urosepsis strains of Escherichia coli bearing pathogenicity island-like domains.
    Infect Immun. 2002 Jun;70(6):3216-26 PMID: 12011017
  16. Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types.
    Antimicrob Agents Chemother. 2002 Sep;46(9):3045-9 PMID: 12183268
  17. Are quinolone-resistant uropathogenic Escherichia coli less virulent?
    J Infect Dis. 2002 Oct 1;186(7):1039-42 PMID: 12232848
  18. Both urinary and rectal Escherichia coli isolates are dominated by strains of phylogenetic group B2.
    J Clin Microbiol. 2002 Nov;40(11):3951-5 PMID: 12409357
  19. Identification and broad dissemination of the CTX-M-14 beta-lactamase in different Escherichia coli strains in the northwest area of Spain.
    J Clin Microbiol. 2002 Nov;40(11):4030-6 PMID: 12409370
  20. Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases.
    Antimicrob Agents Chemother. 2002 Dec;46(12):4038-40 PMID: 12435721
  21. Phylogenetic background and virulence profiles of fluoroquinolone-resistant clinical Escherichia coli isolates from the Netherlands.
    J Infect Dis. 2002 Dec 15;186(12):1852-6 PMID: 12447775
  22. Molecular analysis and experimental virulence of French and North American Escherichia coli neonatal meningitis isolates: identification of a new virulent clone.
    J Infect Dis. 2003 Jun 15;187(12):1895-906 PMID: 12792866
  23. Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans.
    J Infect Dis. 2003 Sep 1;188(5):759-68 PMID: 12934193
  24. Insertion sequence ISEcp1B is involved in expression and mobilization of a bla(CTX-M) beta-lactamase gene.
    Antimicrob Agents Chemother. 2003 Sep;47(9):2938-45 PMID: 12936998
  25. Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States.
    Antimicrob Agents Chemother. 2004 Apr;48(4):1295-9 PMID: 15047532
  26. Phylogenetic distribution of branched RNA-linked multicopy single-stranded DNA among natural isolates of Escherichia coli.
    J Bacteriol. 1990 Nov;172(11):6175-81 PMID: 1699928
  27. Association of carboxylesterase B electrophoretic pattern with presence and expression of urovirulence factor determinants and antimicrobial resistance among strains of Escherichia coli that cause urosepsis.
    Infect Immun. 1991 Jul;59(7):2311-5 PMID: 1675626
  28. Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes.
    Nucleic Acids Res. 1991 Dec 25;19(24):6823-31 PMID: 1762913
  29. Nosocomial colonization and infection with multiresistant Acinetobacter baumannii: outbreak delineation using DNA macrorestriction analysis and PCR-fingerprinting.
    J Hosp Infect. 1993 Sep;25(1):15-32 PMID: 7901273
  30. Correspondence analysis in medical research.
    Stat Methods Med Res. 1992;1(1):97-117 PMID: 1341654
  31. Sex in Escherichia coli does not disrupt the clonal structure of the population: evidence from random amplified polymorphic DNA and restriction-fragment-length polymorphism.
    J Mol Evol. 1995 Oct;41(4):440-8 PMID: 7563131
  32. Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.
    Antimicrob Agents Chemother. 1997 Mar;41(3):647-53 PMID: 9056008
  33. Epidemiological typing of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates responsible for five outbreaks in a university hospital.
    J Hosp Infect. 1997 May;36(1):23-36 PMID: 9172043
  34. Common themes in microbial pathogenicity revisited.
    Microbiol Mol Biol Rev. 1997 Jun;61(2):136-69 PMID: 9184008
  35. Chromosomal regions specific to pathogenic isolates of Escherichia coli have a phylogenetically clustered distribution.
    J Bacteriol. 1998 Mar;180(5):1159-65 PMID: 9495754
  36. Phylogenetic analysis of Escherichia coli strains causing neonatal meningitis suggests horizontal gene transfer from a predominant pool of highly virulent B2 group strains.
    J Infect Dis. 1998 Mar;177(3):642-50 PMID: 9498443
  37. Quinolone resistance from a transferable plasmid.
    Lancet. 1998 Mar 14;351(9105):797-9 PMID: 9519952
  38. [Enterobacteria producing extended spectrum beta-lactamases].
    Pathol Biol (Paris). 1998 Apr;46(4):235-43 PMID: 9769903
  39. Clonal origin, virulence factors, and virulence.
    Infect Immun. 2000 Jan;68(1):424-5 PMID: 10636718
Article Info
Journal
Emerging infectious diseases
Abbr.
Emerg Infect Dis
ISSN
1080-6040
DOI
10.3201/eid1101.040257
Email
catherine.branger@lmr.ap-hop-paris.fr
Published
2005-01-00
Pages
54-61
Language
English
Region
United States
NLM ID
9508155
PMCID
PMC3294364
Subset
IM
External Links
PubMed source DOI: 10.3201/eid1101.040257 PMC Full Text View journal details
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