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PMID: 15676028 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Hepatocyte progenitors in man and in rodents--multiple pathways, multiple candidates.

International journal of experimental pathology ·Vol. 86 ·No. 1 ·2005-02-00 ·Pages 1-18

Laurson J, Selden C, Hodgson HJ

Abstract

In severe injury, liver-cell progenitors may play a role in recovery, proliferating, and subsequently differentiating into mature liver cells. Identifying these progenitors has major therapeutic potential for ex vivo pharmaceutical testing, bioartificial liver support, tissue engineering and gene therapy protocols. Potential liver-cell progenitors have been identified from bone marrow, peripheral blood, cord blood, foetal liver, adult liver and embryonic stem cells. Differences and similarities are found among cells isolated from rodents and humans. This review will discuss identifying markers and differentiation potential in in vitro and in vivo models of these putative progenitors in both humans and rodents.

MeSH Terms
Animals Bone Marrow Cells/cytology Cell Differentiation Fetal Blood/cytology Hepatocytes/cytology Humans Liver/embryology Liver Regeneration/physiology Mice Rats Stem Cells/cytology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Laurson Joanna
Centre for Hepatology, Royal Free and University College Medical School, Hampstead, London, UK.
Selden Clare
Hodgson Humphrey J F
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Article Info
Journal
International journal of experimental pathology
Abbr.
Int J Exp Pathol
ISSN
0959-9673
DOI
10.1111/j.0959-9673.2005.00410.x
Published
2005-02-00
Pages
1-18
Language
English
Region
England
NLM ID
9014042
PMCID
PMC2517398
Subset
IM
External Links
PubMed source DOI: 10.1111/j.0959-9673.2005.00410.x PMC Full Text View journal details
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