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PMID: 15663867 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genome sequence and attenuating mutations in West Nile virus isolate from Mexico.

Emerging infectious diseases ·Vol. 10 ·No. 12 ·2004-12-00 ·Pages 2221-4

Beasley DW, Davis CT, Estrada-Franco J, Navarro-Lopez R, Campomanes-Cortes A, Tesh RB, Weaver SC, Barrett AD

Abstract

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

MeSH Terms

Animals Base Sequence Female Genome, Viral Mexico Mice Mutation Virulence/genetics West Nile virus/genetics,pathogenicity

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Beasley David W C

University of Texas Medical Branch, Galveston, Texas 77555-0609, USA. d.beasley@utmb.edu

Davis C Todd

Estrada-Franco Jose

Navarro-Lopez Roberto

Campomanes-Cortes Arturo

Tesh Robert B

Weaver Scott C

Barrett Alan D T

References (13)

13 references, click to expand

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Article Info

Journal

Emerging infectious diseases

Abbr.

Emerg Infect Dis

ISSN

1080-6040

DOI

10.3201/eid1012.040647

d.beasley@utmb.edu

Published

2004-12-00

Pages

2221-4

Language

English

Region

United States

NLM ID

9508155

PMCID

PMC3323401

Subset

Grants

NIAID NIH HHS · N01AI25489 · United States

NIAID NIH HHS · N01-AI25489 · United States

External Links

PubMed source DOI: 10.3201/eid1012.040647 PMC Full Text View journal details

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Genome sequence and attenuating mutations in West Nile virus isolate from Mexico.

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