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PMID: 12438639 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein.

Journal of virology ·Vol. 76 ·No. 24 ·2002-12-00 ·Pages 13097-100

Beasley DW, Barrett AD

Abstract

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Cell Membrane/metabolism Epitope Mapping Mice Neutralization Tests Recombinant Proteins/immunology Viral Envelope Proteins/immunology,physiology Virulence West Nile virus/immunology,pathogenicity
Chemicals
Antibodies, Monoclonal Recombinant Proteins Viral Envelope Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Beasley David W C
WHO Collaborating Center for Tropical Diseases, Sealy Center for Vaccine Development, Department of Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA.
Barrett Alan D T
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/jvi.76.24.13097-13100.2002
Published
2002-12-00
Pages
13097-100
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC136710
Subset
IM
External Links
PubMed source DOI: 10.1128/jvi.76.24.13097-13100.2002 PMC Full Text View journal details
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