Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 4 ·1979-04-00 ·Pages 1663-7

Hensgens LA, Grivell LA, Borst P, Bos JL

Abstract

We have determined the nucleotide sequence of a segment of Saccharomyces mtDNA that contains the structural gene for one of the subunits (the dicyclohexylcarbodiimide-binding protein) of the mitochondrial ATPase complex. The sequence fits the known amino acid sequence of this protein with the exception of one amino acid. Codon usage is biased in favor of A + T-rich codons. On both sides of the gene, the nucleotide sequence contains less than 4% (mol/mol) G + C for at least 180 nucleotides; these A + T sequences show no evidence of internal repetition. The gene and all the A + T-rich sequence preceding the gene are present in a 12S RNA that is the major transcript of this segment of mtDNA. The nature of the sequences responsible for binding ribosomes to mitochondrial mRNA and for termination of RNA synthesis is considered.

MeSH Terms

Adenosine Triphosphatases/biosynthesis Base Sequence Codon DNA, Mitochondrial/metabolism Genes Genetic Code Macromolecular Substances Saccharomyces cerevisiae/enzymology

Chemicals

Codon DNA, Mitochondrial Macromolecular Substances Adenosine Triphosphatases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hensgens L A

Grivell L A

Borst P

Bos J L

References (24)

24 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.76.4.1663

Published

1979-04-00

Pages

1663-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC383450

Subset

Databases

GENBANK

J01460

External Links

PubMed source DOI: 10.1073/pnas.76.4.1663 PMC Full Text View journal details

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Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex.

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