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PMID: 15607967 Published · ppublish English Journal Article Comment

Around the world of DNA damage INO80 days.

Cell ·Vol. 119 ·No. 6 ·2004-12-17 ·Pages 733-5

Cairns BR

Abstract

DNA damage is detected and repaired in the context of chromatin. In this issue of Cell, van Attikum et al. (2004) and Morrison et al. (2004) demonstrate that double-stranded break repair involves the recruitment of a specialized chromatin remodeling complex, INO80, through an interaction with phosphorylated histone H2A.

MeSH Terms
Adenosine Triphosphate/genetics,metabolism Chromatin Assembly and Disassembly/genetics,physiology Chromosomes/genetics,metabolism DNA Damage/genetics,physiology DNA Repair/genetics,physiology DNA-Binding Proteins/genetics,metabolism Histones/genetics,metabolism Mutation/genetics Protein Binding Rad52 DNA Repair and Recombination Protein Saccharomyces cerevisiae/genetics,metabolism Saccharomyces cerevisiae Proteins/genetics,metabolism Transcription, Genetic/genetics,physiology
Chemicals
DNA-Binding Proteins H2AX protein, human Histones INO80 complex, S cerevisiae RAD52 protein, S cerevisiae Rad52 DNA Repair and Recombination Protein Saccharomyces cerevisiae Proteins Adenosine Triphosphate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Cairns Bradley R
Howard Hughes Medical Institute and Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
References (11)
11 references, click to expand
  1. The INO80 protein controls homologous recombination in Arabidopsis thaliana.
    Mol Cell. 2004 Nov 5;16(3):479-85 PMID: 15525519
  2. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions.
    Science. 2004 Dec 17;306(5704):2084-7 PMID: 15528408
  3. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex.
    Mol Cell. 2004 Nov 5;16(3):465-77 PMID: 15525518
  4. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.
    Microbiol Mol Biol Rev. 1999 Jun;63(2):349-404 PMID: 10357855
  5. Cellular machineries for chromosomal DNA repair.
    Genes Dev. 2004 Mar 15;18(6):602-16 PMID: 15075289
  6. A chromatin remodelling complex involved in transcription and DNA processing.
    Nature. 2000 Aug 3;406(6795):541-4 PMID: 10952318
  7. Involvement of actin-related proteins in ATP-dependent chromatin remodeling.
    Mol Cell. 2003 Jul;12(1):147-55 PMID: 12887900
  8. ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.
    Science. 2004 Jan 16;303(5656):343-8 PMID: 14645854
  9. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair.
    Cell. 2004 Dec 17;119(6):777-88 PMID: 15607975
  10. INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.
    Cell. 2004 Dec 17;119(6):767-75 PMID: 15607974
  11. Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites.
    Mol Cell. 2004 Dec 22;16(6):979-90 PMID: 15610740
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/j.cell.2004.12.005
Published
2004-12-17
Pages
733-5
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2788563
Subset
IM
Grants
Howard Hughes Medical Institute · United States
Corrections
CommentOn
PMID: 15607974
CommentOn
PMID: 15607975
External Links
PubMed source DOI: 10.1016/j.cell.2004.12.005 PMC Full Text View journal details
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