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PMID: 15270721 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Divide and conquer: the importance of cell division in regulating B-cell responses.

Immunology ·Vol. 112 ·No. 4 ·2004-08-00 ·Pages 509-20

Tangye SG, Hodgkin PD

Abstract

Proliferation is an essential characteristic of clonal selection and is required for the expansion of antigen reactive clones leading to the development of antibody of different isotypes and memory cells. New data for mouse and human B cells point to an important role for division in regulating isotype class and in optimizing development of protective immunity by the regulated entry of cells to the plasma cell lineage.

MeSH Terms
Animals Antibody Formation/immunology B-Lymphocytes/cytology,immunology Cell Differentiation/immunology Cell Division/immunology Humans Immunoglobulin Class Switching/immunology Immunologic Memory Mice
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tangye Stuart G
Centenary Institute of Cancer Medicine and Cell Biology, Newtown 2042, NSW, Australia. s.tangye@centenary.usyd.edu.au
Hodgkin Philip D
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
DOI
10.1111/j.1365-2567.2004.01950.x
Email
s.tangye@centenary.usyd.edu.au
Published
2004-08-00
Pages
509-20
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1782517
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2567.2004.01950.x PMC Full Text View journal details
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