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PMID: 15226422 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

mRNA capping enzyme activity is coupled to an early transcription elongation.

Molecular and cellular biology ·Vol. 24 ·No. 14 ·2004-07-00 ·Pages 6184-93

Kim HJ, Jeong SH, Heo JH, Jeong SJ, Kim ST, Youn HD, Han JW, Lee HW, Cho EJ

Abstract

One of the temperature-sensitive alleles of CEG1, a guanylyltransferase subunit of the Saccharomyces cerevisiae capping enzyme, showed 6-azauracil (6AU) sensitivity at the permissive growth temperature, which is a phenotype that is correlated with a transcription elongation defect. This temperature-sensitive allele, ceg1-63, has an impaired ability to induce PUR5 in response to 6AU treatment and diminished enzyme-GMP formation activity. However, this cellular and molecular defect is not primarily due to the preferential degradation of the transcript attributed to a lack of cap structure. Our data suggest that the guanylyltransferase subunit of the capping enzyme plays a role in transcription elongation as well as cap formation. First, in addition to the 6AU sensitivity, ceg1-63 is synthetically lethal with elongation-defective mutations in RNA polymerase II. Secondly, it produces a prolonged steady-state level of GAL1 mRNA after glucose shutoff. Third, it decreases the transcription read through a tandem array of promoter-proximal pause sites in an orientation-dependent manner. Taken together, we present direct evidence that suggests a role of capping enzyme in an early transcription. Capping enzyme ensures the early transcription checkpoint by capping of the nascent transcript in time and allowing it to extend further.

MeSH Terms
Alleles Antimetabolites/metabolism Cell Division Gene Expression Regulation, Fungal Humans Mutation Nucleotidyltransferases/genetics,metabolism Promoter Regions, Genetic Protein Subunits/genetics,metabolism RNA Caps Saccharomyces cerevisiae/genetics,metabolism Saccharomyces cerevisiae Proteins/genetics,metabolism Temperature Transcription, Genetic Uracil/analogs & derivatives,metabolism
Chemicals
Antimetabolites Protein Subunits RNA Caps Saccharomyces cerevisiae Proteins Uracil Nucleotidyltransferases mRNA guanylyltransferase azauracil
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Kim Hye-Jin
Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi-do 440-746, South Korea.
Jeong Seok-Ho
Heo Jeong-Hwa
Jeong Su-Jin
Kim Seong-Tae
Youn Hong-Duk
Han Jeong-Whan
Lee Hyang-Woo
Cho Eun-Jung
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
Published
2004-07-00
Pages
6184-93
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC434235
Subset
IM
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