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PMID: 15139300 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Chemokines and glial cells: a complex network in the central nervous system.

Neurochemical research ·Vol. 29 ·No. 5 ·2004-05-00 ·Pages 1017-38

Ambrosini E, Aloisi F

Abstract

Chemokines are small secreted proteins that are essential for the recruitment and activation of specific leukocyte subsets at sites of inflammation and for the development and homeostasis of lymphoid and nonlymphoid tissues. During the past decade, chemokines and their receptors have also emerged as key signaling molecules in neuroinflammatory processes and in the development and functioning of the central nervous system. Neurons and glial cells, including astrocytes, oligodendrocytes, and microglia, have been identified as cellular sources and/or targets of chemokines produced in the central nervous system in physiological and pathological conditions. In this article, we provide an update of chemokines and chemokine receptors expressed by glial cells focusing on their biological functions and implications in neurological diseases.

MeSH Terms
Animals Central Nervous System/cytology,physiology Chemokines/biosynthesis,physiology Humans Neuroglia/cytology,physiology Receptors, Chemokine/metabolism
Chemicals
Chemokines Receptors, Chemokine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ambrosini Elena
Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. ambrosin@iss.it
Aloisi Francesca
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1023/b:nere.0000021246.96864.89
Email
ambrosin@iss.it
Published
2004-05-00
Pages
1017-38
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1023/b:nere.0000021246.96864.89 View journal details
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