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PMID: 1503452 Published · ppublish English Journal Article

Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 4 ·1992-04-00 ·Pages 876-8

Oliva B, Chopra I

Abstract

Atypical tetracyclines were active against Escherichia coli and Staphylococcus aureus strains containing determinants that mediate resistance to typical tetracyclines by efflux (Tet B and Tet K) or ribosomal protection (Tet M) mechanisms. The results support recently published data that tetracyclines are divisible into at least two classes on the basis of their modes of action.

MeSH Terms
Escherichia coli/drug effects Microbial Sensitivity Tests Staphylococcus aureus/drug effects Tetracyclines/classification,pharmacology
Chemicals
Tetracyclines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oliva B
Department of Microbial Biochemistry and Genetics, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965.
Chopra I
References (13)
13 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.36.4.876
Published
1992-04-00
Pages
876-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC189478
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.36.4.876 PMC Full Text View journal details
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