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PMID: 2990331 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Resistance to various tetracyclines mediated by transposon Tn10 in Escherichia coli K-12.

Antimicrobial agents and chemotherapy ·Vol. 27 ·No. 5 ·1985-05-00 ·Pages 879-81

Traub B, Beck CF

Abstract

Levels of resistance to tetracycline, chlortetracycline, demethylchlortetracycline, doxycycline, oxytetracycline, methacycline, pyrrolidinotetracycline, minocycline, and beta-chelocardin of Escherichia coli K-12 carrying transposon Tn10 or defined DNA segments of Tn10 were determined. In all cases, tetA was the only gene required for resistance. Doxycycline was the most effective inducer of tetA gene expression.

MeSH Terms
DNA Transposable Elements Drug Resistance, Microbial Escherichia coli/drug effects,genetics Gene Expression Regulation Tetracyclines/pharmacology
Chemicals
DNA Transposable Elements Tetracyclines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Traub B
Beck C F
References (13)
13 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.27.5.879
Published
1985-05-00
Pages
879-81
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC180172
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.27.5.879 PMC Full Text View journal details
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