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PMID: 15032692 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Inhibition of MHC II gene transcription by nitric oxide and antioxidants.

Current pharmaceutical design ·Vol. 10 ·No. 8 ·2004-00-00 ·Pages 893-8

Harari O, Liao JK

Abstract

MHC class II molecules are expressed on the surface of antigen presenting cells and are loaded with peptides processed from the phagosomal compartment of these cells. Such complexes interact with the CD4 positive T lymphocyte receptor for antigen and a strong interaction is followed by T cell activation and proliferation. As class II expression is critical for antigen specific immunity its expression mostly restricted to a few cell types but can be induced on others in response to interferon gamma. This expansion of antigen presenting ability plays a role in increasing the duration and intensity of the immune response. Nitric oxide and antioxidants attenuate this class II induction through negative effects on the induction of class II transactivator protein expression and on the binding of transcription factor NF-Y to the class II promoter.

MeSH Terms
Animals Antigen-Presenting Cells/immunology,physiology Antioxidants/metabolism Genes, MHC Class II Histocompatibility Antigens Class II/biosynthesis Humans Nitric Oxide/physiology Transcription, Genetic
Chemicals
Antioxidants Histocompatibility Antigens Class II Nitric Oxide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Harari Olivier
Vascular Medicine Research, Brigham & Women's Hospital, 65 Landsdowne Street, Room 275, Cambridge, Massachusetts 02139, USA.
Liao James K
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Article Info
Journal
Current pharmaceutical design
Abbr.
Curr Pharm Des
ISSN
1381-6128
DOI
10.2174/1381612043452893
Published
2004-00-00
Pages
893-8
Language
English
Region
United Arab Emirates
NLM ID
9602487
PMCID
PMC2633593
Subset
IM
Grants
NINDS NIH HHS · P01 NS010828 · United States
NIDDK NIH HHS · R01 DK062729-01A1 · United States
NINDS NIH HHS · P01 NS010828-330036 · United States
NHLBI NIH HHS · HL48743 · United States
NHLBI NIH HHS · HL52233 · United States
NINDS NIH HHS · P50 NS010828 · United States
NHLBI NIH HHS · R01 HL052233-06 · United States
Wellcome Trust · United Kingdom
NHLBI NIH HHS · R01 HL070274 · United States
NINDS NIH HHS · P50 NS010828-290036 · United States
NHLBI NIH HHS · P01 HL048743-120008 · United States
NHLBI NIH HHS · R01 HL070274-02 · United States
NHLBI NIH HHS · P01 HL048743 · United States
NHLBI NIH HHS · R01 HL052233-05 · United States
NHLBI NIH HHS · R01 HL070274-01 · United States
NHLBI NIH HHS · R01 HL052233 · United States
NIDDK NIH HHS · R01 DK062729 · United States
External Links
PubMed source DOI: 10.2174/1381612043452893 PMC Full Text View journal details
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