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PMID: 1500861 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Memory T cells are anergic to the superantigen staphylococcal enterotoxin B.

The Journal of experimental medicine ·Vol. 176 ·No. 2 ·1992-08-01 ·Pages 575-9

Lee WT, Vitetta ES

Abstract

We have used staphylococcal enterotoxin B (SEB) to study the role of naive and memory T cells in the induction of peripheral tolerance. After administration of SEB to mice, the numbers of naive and memory T cells increase, as does the proportion of memory T cells, which are unresponsive to further stimulation with SEB in vitro. In addition, memory T cells generated in response to conventional antigen, which proliferate and provide help to B cells in the presence of the conventional antigen, fail to respond to superantigen. Hence, memory T cells, in general, are anergized by SEB. These results suggest that SEB-induced activation and anergy reflect the combined responses of naive and memory T cells. The differential activation vs. anergy of naive and memory T cells by superantigen may be related to cytokine production and may play an important role in the etiology of autoimmune diseases or immunodeficiency diseases such as acquired immune deficiency syndrome.

MeSH Terms

Animals Antigens, Bacterial/immunology Cells, Cultured Enterotoxins/immunology Female Immunologic Memory Mice Mice, Inbred BALB C Staphylococcus aureus/immunology T-Lymphocytes/immunology

Chemicals

Antigens, Bacterial Enterotoxins enterotoxin B, staphylococcal

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lee W T

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.

Vitetta E S

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21 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.176.2.575

Published

1992-08-01

Pages

575-9

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2119322

Subset

Grants

NIAID NIH HHS · AI-11851 · United States

NIAID NIH HHS · AI-21229 · United States

External Links

PubMed source DOI: 10.1084/jem.176.2.575 PMC Full Text View journal details

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Memory T cells are anergic to the superantigen staphylococcal enterotoxin B.

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